FDX1 and PRKAB2

Number of citations of the paper that reports this interaction (PubMedID 19616115)
10

Data Source:
BioGRID (two hybrid)

		FDX1	PRKAB2
Description		ferredoxin 1	protein kinase AMP-activated non-catalytic subunit beta 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Iron Ion Binding Electron Transfer Activity 2 Iron, 2 Sulfur Cluster Binding	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	C21-steroid Hormone Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Small Molecule Metabolic Process Cellular Response To CAMP Cellular Response To Forskolin	Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Mitotane	Adenosine monophosphate Acetylsalicylic acid
Diseases
GWAS		Cognitive function ( 24684796)
Interacting Genes		5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2	74 interacting genes: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FDX1 FLNC GATA1 GATAD2B GET4 GOLGA2 GRN IHO1 IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PNMA1 PRDM14 PRKAA1 PRKAG1 PRKAG2 PSME3 PYGM RACK1 RBPMS REL RHEBL1 RIMBP3 SPRY2 SSX2IP STX11 STX19 TADA2A TASOR2 TCF4 TLE5 TP53 TP53BP2 TRAF1 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32
Entrez ID		2230	5565
HPRD ID		00059	04117
Ensembl ID		ENSG00000137714	ENSG00000131791
Uniprot IDs		P10109	O43741
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M	2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E
Enriched GO Terms of Interacting Partners?
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