FARSA and ECSIT

Number of citations of the paper that reports this interaction (PubMedID 21163940)
33

Data Source:
BioGRID (two hybrid, pull down)

		FARSA	ECSIT
Description		phenylalanyl-tRNA synthetase subunit alpha	ECSIT signaling integrator
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Phenylalanine-tRNA Ligase Complex Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	TRNA Binding RNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation Protein Heterotetramerization	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Cytosolic tRNA aminoacylation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs		L-Phenylalanine
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Type 2 diabetes ( 30297969)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		9 interacting genes: A2M ABI3 APOE ECSIT ESR1 GORAB HNRNPR RNF32 TDGF1	50 interacting genes: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CNN1 CORO2B CYP2C18 CYP2C8 CYP2C9 DNAJB1 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MARCHF2 MAST1 MRPL4 NDUFA13 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		2193	51295
HPRD ID		04227	12225
Ensembl ID		ENSG00000179115	ENSG00000130159
Uniprot IDs		Q6IBR2 Q9Y285	Q9BQ95
PDB IDs		3L4G
Enriched GO Terms of Interacting Partners?
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