ECSIT and CYP2C8

Number of citations of the paper that reports this interaction (PubMedID 21163940)
33

Data Source:
BioGRID (two hybrid)

		ECSIT	CYP2C8
Description		ECSIT signaling integrator	cytochrome P450 family 2 subfamily C member 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Caffeine Oxidase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Lipid Hydroxylation Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Retinol Metabolic Process Retinoic Acid Metabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs
Drugs			Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Blood metabolite levels ( 24816252) Gout ( 22179738) Immune response to smallpox vaccine (IL-6) ( 22542470) Osteonecrosis of the jaw ( 18594024) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Response to clopidogrel therapy ( 19706858) Tuberculosis ( 24057671) Urinary metabolite levels in chronic kidney disease ( 31959995) Warfarin maintenance dose ( 23755828)
Interacting Genes		50 interacting genes: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CNN1 CORO2B CYP2C18 CYP2C8 CYP2C9 DNAJB1 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MARCHF2 MAST1 MRPL4 NDUFA13 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59	12 interacting genes: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RIN3 RNF32
Entrez ID		51295	1558
HPRD ID		12225	03083
Ensembl ID		ENSG00000130159	ENSG00000138115
Uniprot IDs		Q9BQ95	B7Z1F5 P10632
PDB IDs			1PQ2 2NNH 2NNI 2NNJ 2VN0
Enriched GO Terms of Interacting Partners?
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