ECSIT and IFIT5

Number of citations of the paper that reports this interaction (PubMedID 21163940)
33

Data Source:
BioGRID (two hybrid)

		ECSIT	IFIT5
Description		ECSIT signaling integrator	interferon induced protein with tetratricopeptide repeats 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Cytosol Plasma Membrane IkappaB Kinase Complex Actin Cytoskeleton Ruffle Membrane Apical Part Of Cell
	Molecular Function	Protein Binding	TRNA Binding RNA Cap Binding Double-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		50 interacting genes: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CNN1 CORO2B CYP2C18 CYP2C8 CYP2C9 DNAJB1 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MARCHF2 MAST1 MRPL4 NDUFA13 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59	17 interacting genes: A2M APOE CDC37 CHUK ECSIT IFIT1 IFIT3 IKBKG LONP1 MAST1 PRDX2 PSEN2 RAD23A RNF32 SARAF SRPK1 SRPK2
Entrez ID		51295	24138
HPRD ID		12225	17130
Ensembl ID		ENSG00000130159	ENSG00000152778
Uniprot IDs		Q9BQ95	Q13325
PDB IDs			3ZGQ 4HOQ 4HOR 4HOS 4HOT 4J0U
Enriched GO Terms of Interacting Partners?
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