MECOM and MBD3

Number of citations of the paper that reports this interaction (PubMedID 18500823)
7

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MECOM	MBD3
Description		MDS1 and EVI1 complex locus	methyl-CpG binding domain protein 3
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol Nuclear Speck	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Apoptotic Process Regulation Of Gene Expression Hemopoiesis Cell Differentiation Negative Regulation Of Programmed Cell Death Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Histone H3-K9 Methylation Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator
Pathways		PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases		Chronic myeloid leukemia (CML)
GWAS		Aging (time to event) ( 21782286) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 31152163 29403010) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glomerular filtration rate ( 29403010) Height ( 31562340) Hematocrit ( 27863252) Hematology traits ( 30576415) Intraocular pressure ( 29617998 29785010 31959993 30054594) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Myeloproliferative neoplasms ( 25849990) Nasopharyngeal carcinoma ( 26545403) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 27863252) Plateletcrit ( 27863252) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 27863252) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528)
Interacting Genes		15 interacting genes: CREBBP CTBP1 CTBP2 HDAC1 HDAC4 HIC1 KAT2B MBD3 PIK3R3 PRMT1 SMAD1 SMAD2 SMAD3 SMAD4 UBE2I	29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277
Entrez ID		2122	53615
HPRD ID		01310	04653
Ensembl ID		ENSG00000085276	ENSG00000071655
Uniprot IDs		A0A0C3SFZ7 C7FEN9 Q03112	O95983
PDB IDs		6BW3	2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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