MECOM and CTBP2

Number of citations of the paper that reports this interaction (PubMedID 9724649)
117

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MECOM	CTBP2
Description		MDS1 and EVI1 complex locus	C-terminal binding protein 2
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol Nuclear Speck	Nucleus Transcriptional Repressor Complex Cell Junction Photoreceptor Ribbon Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Retinoic Acid Receptor Binding Protein-containing Complex Binding NAD Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Apoptotic Process Regulation Of Gene Expression Hemopoiesis Cell Differentiation Negative Regulation Of Programmed Cell Death Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Histone H3-K9 Methylation Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation	Negative Regulation Of Cell Proliferation Synaptic Vesicle Docking Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Maintenance Of Presynaptic Active Zone Structure White Fat Cell Differentiation Oxidation-reduction Process Cellular Response To Leukemia Inhibitory Factor
Pathways		PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Repression of WNT target genes TCF7L2 mutants don't bind CTBP
Drugs
Diseases		Chronic myeloid leukemia (CML)
GWAS		Aging (time to event) ( 21782286) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 31152163 29403010) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glomerular filtration rate ( 29403010) Height ( 31562340) Hematocrit ( 27863252) Hematology traits ( 30576415) Intraocular pressure ( 29617998 29785010 31959993 30054594) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Myeloproliferative neoplasms ( 25849990) Nasopharyngeal carcinoma ( 26545403) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 27863252) Plateletcrit ( 27863252) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 27863252) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528)	Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Body mass index ( 25673413 29273807) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Height ( 25429064) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Prostate cancer ( 18264096) Vigorous physical activity ( 29899525)
Interacting Genes		15 interacting genes: CREBBP CTBP1 CTBP2 HDAC1 HDAC4 HIC1 KAT2B MBD3 PIK3R3 PRMT1 SMAD1 SMAD2 SMAD3 SMAD4 UBE2I	67 interacting genes: ACTG1 AKTIP APP ATE1 BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 H3-4 HIC1 HOXB5 IKZF2 KCNIP3 KLF3 KLF8 MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBC UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750
Entrez ID		2122	1488
HPRD ID		01310	04016
Ensembl ID		ENSG00000085276	ENSG00000175029
Uniprot IDs		A0A0C3SFZ7 C7FEN9 Q03112	P56545
PDB IDs		6BW3	2OME 4LCJ
Enriched GO Terms of Interacting Partners?
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