ETS2 and STAT5B

Number of citations of the paper that reports this interaction (PubMedID 10815800)
12

Data Source:
HPRD (in vitro, in vivo)

		ETS2	STAT5B
Description		ETS proto-oncogene 2, transcription factor	signal transducer and activator of transcription 5B
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation	Luteinization Natural Killer Cell Differentiation Regulation Of Transcription By RNA Polymerase II Defense Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-4 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Mast Cell Migration
Pathways		Oncogene Induced Senescence	Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Dasatinib
Diseases			Growth hormone insensitivity with immunodeficiency
GWAS		Body mass index ( 25673413) C-reactive protein levels ( 30388399) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Inflammatory bowel disease ( 27569725 28067908 23128233) Paracentral lobule volume ( 31530798) Ulcerative colitis ( 28067908)
Interacting Genes		20 interacting genes: CDK10 COP1 CREBBP EP300 ERG ETS1 FOS GATA3 JUN NCOR1 NR3C1 POU5F1 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11	49 interacting genes: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG
Entrez ID		2114	6777
HPRD ID		01263	05037
Ensembl ID		ENSG00000157557	ENSG00000173757
Uniprot IDs		P15036	P51692
PDB IDs		4BQA 4MHV	6MBW 6MBZ
Enriched GO Terms of Interacting Partners?
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