ETS2 and POU5F1

Number of citations of the paper that reports this interaction (PubMedID 11689681)
21

Data Source:
HPRD (in vivo, in vitro)

		ETS2	POU5F1
Description		ETS proto-oncogene 2, transcription factor	POU class 5 homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Blastocyst Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Cell Differentiation Somatic Stem Cell Population Maintenance MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Silencing By MiRNA
Pathways		Oncogene Induced Senescence	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Body mass index ( 25673413) C-reactive protein levels ( 30388399) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cold sores ( 28928442) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21801394) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Multiple myeloma ( 23955597) Night sleep phenotypes ( 27126917) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Type 2 diabetes ( 24509480 30718926 28869590) Ulcerative colitis ( 28067908)
Interacting Genes		20 interacting genes: CDK10 COP1 CREBBP EP300 ERG ETS1 FOS GATA3 JUN NCOR1 NR3C1 POU5F1 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11	15 interacting genes: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH LRRK2 MNAT1 NR0B1 SOX10 SOX2 SOX8 STUB1 WDR5
Entrez ID		2114	5460
HPRD ID		01263	01252
Ensembl ID		ENSG00000157557	ENSG00000204531
Uniprot IDs		P15036	D2IYK3 F2Z381 M1S623 Q01860
PDB IDs		4BQA 4MHV
Enriched GO Terms of Interacting Partners?
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