ESR1 and GTF2H1

Number of citations of the paper that reports this interaction (PubMedID 10949034)
80

Data Source:
HPRD (in vivo, in vitro)

		ESR1	GTF2H1
Description		estrogen receptor 1	general transcription factor IIH subunit 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Integral Component Of Membrane Protein-containing Complex Transcriptionally Active Chromatin Transcriptional Preinitiation Complex	Transcription Factor TFIIH Core Complex Nucleoplasm Transcription Factor TFIIH Holo Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Enzyme Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Estrogen Receptor Activity Estrogen Receptor Binding Estrogen Response Element Binding Identical Protein Binding ATPase Binding	Chromatin Binding Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Antral Ovarian Follicle Growth Epithelial Cell Development Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Androgen Metabolic Process Male Gonad Development Negative Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Protein Deubiquitination Regulation Of Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Response To Estradiol Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA-binding Transcription Factor Activity Response To Estrogen Positive Regulation Of Transcription, DNA-templated Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Stem Cell Differentiation Regulation Of Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Uterus Development Vagina Development Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Protein Localization To Chromatin Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Nucleotide-excision Repair, DNA Incision Positive Regulation Of Transcription By RNA Polymerase II Phosphorylation Of RNA Polymerase II C-terminal Domain Global Genome Nucleotide-excision Repair
Pathways		Nuclear signaling by ERBB4 PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors RUNX1 regulates estrogen receptor mediated transcription ESR-mediated signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Extra-nuclear estrogen signaling Estrogen-dependent gene expression	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs		Diethylstilbestrol Chlorotrianisene Conjugated estrogens Etonogestrel Desogestrel Levonorgestrel Progesterone Lindane Raloxifene Toremifene Medroxyprogesterone acetate Testosterone Mitotane Estrone Tamoxifen Hexachlorophene Estradiol Ethynodiol diacetate Dobutamine Clomifene Dienestrol Fulvestrant Norgestimate Ethinyl Estradiol Melatonin Trilostane Naloxone Fluoxymesterone Estramustine Mestranol Danazol Oxybenzone Allylestrenol Zinc Genistein Prasterone Benzophenone Equilin Compound 19 Resveratrol Compound 18 Phthalic Acid Pyrazole Dihydrotestosterone Naringenin Compound 4-D 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol Quercetin Afimoxifene 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol Estriol Estrone sulfate Quinestrol Phenolphthalein Permethrin Ospemifene AP1081 Custirsen NP-50301 CHF 4227 Lasofoxifene Bazedoxifene Methyltestosterone beta-Naphthoflavone 17-METHYL-17-ALPHA-DIHYDROEQUILENIN 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL Hexestrol dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate Erteberel N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL RALOXIFENE CORE Tibolone Eugenol Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, B Octocrylene Homosalate Phenyl salicylate Enzacamene Propyl Gallate 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol
Diseases
GWAS		Age at first birth ( 27089180 27798627) Age at first sexual intercourse ( 27089180) Alcohol dependence ( 19581569) Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone mineral density ( 23437003) Bone mineral density (hip) ( 19079262 19801982 18445777) Bone mineral density (spine) ( 30172743 19079262 26911590 19801982 27424934 18445777) Bone mineral density (Ward's triangle area) ( 27397699) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22383897 21263130 25327703 19219042 29059683 23535729 23535733 27117709 31757997 20453838) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Breast size ( 22747683 29855537 27182965) Chronic myeloid leukemia ( 21540461) Developmental language disorder ( 27016271) Diastolic blood pressure ( 30578418) Endometriosis ( 28537267) Fractures ( 30158200) Heel bone mineral density ( 31453325 30598549 30048462 28869591) Heel bone mineral density variance ( 31453325) Height ( 28552196 20881960 25282103 23563607 31562340) Mammographic density (dense area) ( 25342443) Menarche (age at onset) ( 25231870) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 28135244 27841878 30578418) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (dichotomous) ( 28628665) Smoking status (current vs former) ( 27393504) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 27841878 30578418) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 28552196) Western dietary pattern ( 28644415)	Amyloid A serum levels ( 21124955) Blood protein levels ( 28240269) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944) Survival in pancreatic cancer ( 28470677)
Interacting Genes		370 interacting genes: ACTB ACTN4 AHR AKAP13 AKT1 AKT2 ALYREF ANGPTL4 ANP32B AR ARHGEF15 ARID1A ARNT ATAD2 BAG1 BAP1 BARD1 BCAR1 BCAS2 BDNF BRCA1 BTF3 CALM1 CALM2 CALM3 CAV1 CBLL1 CCNC CCND1 CCNH CCNT1 CCT2 CDC25B CDK2 CDK7 CDK8 CDKN1A CEBPA CEBPB CFL1 CHD9 CHUK CIRBP CITED1 COPS5 CREBBP CSNK2B CSRP1 CTNNB1 CUEDC2 CUL4B CXCL1 DAP3 DARS1 DBN1 DDX1 DDX17 DDX3X DDX5 DDX54 DHX9 DNMT3L DNTTIP2 DUT EEF2 EGFR EHMT2 EIF2S2 EIF3I EIF4A1 EIF4A3 EIF5A EP300 EPAS1 EPRS1 EPSTI1 ERBB2 ESR2 ESRRA FARSA FBH1 FHL2 FKBP4 FKBP5 FLII FOXK2 FOXO1 FOXO3 FOXO4 FUBP1 GADD45B GADD45G GLCE GNAI1 GRB2 GRIP1 GRWD1 GTF2B GTF2H1 H2AC20 H2BC10 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H3-3A H3-3B HBP1 HDAC3 HDAC4 HDAC5 HDAC9 HDLBP HEXIM1 HNF4A HNRNPA1 HNRNPA2B1 HNRNPC HNRNPD HSP90AA1 HSP90AB1 HSP90B1 HSPA4 HSPA8 HSPB1 IGF1R ILF3 ING1 ISL1 ITGB3BP JUN JUNB JUND KARS1 KAT5 KDM5A KIF1A KLF5 KLK5 KLK9 KMT2D KMT5B KRT10 KRT18 KRT19 KRT8 LARS1 LCK LCOR LDB1 LINC00312 LRIF1 MAPK1 MAPK14 MAPK3 MARS1 MDM2 MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED27 MED6 MED7 MEN1 MGMT MKNK2 MMS19 MNAT1 MPG MSH2 MTA1 MTA2 MTCH2 MTHFD1 MTOR MUC1 MVP MYBBP1A MYH6 NAP1L4 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOA7 NCOR1 NCOR2 NELFB NFKB1 NONO NPM1 NPPA NR0B1 NR0B2 NR1H4 NR2C1 NR2C2 NR2F1 NR2F6 NRIP1 NSD1 NSD2 NSD3 NSF NUDT21 OTUB1 P4HB PA2G4 PAGR1 PAK1 PAK6 PBXIP1 PDIA3 PELP1 PGC PGR PHB PHB2 PIAS1 PIAS2 PIAS3 PIK3R1 PIK3R3 PNRC2 POLR1B POLR2A POLR2D POU2F1 POU2F2 POU4F1 POU4F2 PPARGC1A PPARGC1B PPIB PPID PPP1CA PPP2R1A PQBP1 PRDM2 PRKACA PRKCSH PRMT1 PRMT2 PRPF19 PRPF6 PSMC3IP PSMC5 PSMD1 PSPC1 PTEN PTGES3 PTMA PTPN1 PTPN6 RAC3 RACK1 RANBP9 RARA RBBP4 RBBP7 RBFOX2 RBM23 RBM39 RELA REXO4 RFX4 RGS3 RLIM RNF14 RNF4 RPL9 RPS6KA1 RPS6KA3 RTCB RXRA SAFB SAFB2 SARNP SARS2 SEPTIN2 SEPTIN8 SERBP1 SERPINB5 SET SETD7 SFPQ SHC1 SHMT2 SKIL SKP2 SLC30A9 SMAD2 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCD3 SMARCE1 SMC1A SMC3 SMYD2 SND1 SNX6 SOS1 SP1 SP3 SRA1 SRC SREBF1 STAT5A STRN STUB1 SUV39H1 SVIL SYNCRIP TADA3 TAF10 TAF1A TAF1B TAF2 TAP1 TBP TCERG1 TCF20 TDG THRA THRB TNFRSF14 TOPBP1 TP53 TRAM1 TRIM24 TRIM25 TRIM28 TRIM59 TRIP4 TRRAP TSC2 TUBA1B TUBA1C TUBB TXNRD1 UBE2D3 UBE2I UBE4B UIMC1 USF1 VAV3 VCP WBP2 WIPI1 XBP1 YARS1 YWHAH YWHAQ ZBTB16 ZBTB17 ZNF398	44 interacting genes: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 PIK3R1 PLCG1 POLR2A POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1
Entrez ID		2099	2965
HPRD ID		00589	01807
Ensembl ID		ENSG00000091831	ENSG00000110768
Uniprot IDs		A0A125SXW3 A8KAF4 G4XH65 H0Y4W6 P03372 Q9UBT1	A0A384MTQ8 P32780
PDB IDs		1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2B1Z 2B23 2BJ4 2FAI 2G44 2G5O 2I0J 2IOG 2IOK 2JF9 2JFA 2LLO 2LLQ 2OCF 2OUZ 2P15 2POG 2Q6J 2Q70 2QA6 2QA8 2QAB 2QE4 2QGT 2QGW 2QH6 2QR9 2QSE 2QXM 2QXS 2QZO 2R6W 2R6Y 2YAT 2YJA 3CBM 3CBO 3CBP 3DT3 3ERD 3ERT 3HLV 3HM1 3L03 3OS8 3OS9 3OSA 3Q95 3UU7 3UUA 3UUC 3UUD 4AA6 4DMA 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4JC3 4JDD 4MG5 4MG6 4MG7 4MG8 4MG9 4MGA 4MGB 4MGC 4MGD 4O6F 4PP6 4PPP 4PPS 4PXM 4Q13 4Q50 4TUZ 4TV1 4XI3 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 5AAU 5AAV 5ACC 5AK2 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EGV 5EHJ 5EI1 5EIT 5FQP 5FQR 5FQS 5FQT 5FQV 5GS4 5GTR 5HYR 5JMM 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5N10 5T0X 5T1Z 5T92 5T97 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5TN9 5TNB 5U2B 5U2D 5UFW 5UFX 5W9C 5W9D 5WGD 5WGQ 6B0F 6C42 6CBZ 6CHW 6CHZ 6CZN 6D0F 6DF6 6DFN 6HHP 6HKB 6HKF 6HMU 6IAR 6OWC 6PET 6PFM 6PIT 6PSJ 6SBO 6SQ0 6SUO	1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M
Enriched GO Terms of Interacting Partners?
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