CTTN and HAX1

Number of citations of the paper that reports this interaction (PubMedID 15159385)
24

Data Source:
HPRD (in vitro)

		CTTN	HAX1
Description		cortactin	HCLS1 associated protein X-1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Postsynaptic Density Lamellipodium Dendrite Growth Cone Site Of Polarized Growth Cortical Cytoskeleton Cortical Actin Cytoskeleton Dendritic Spine Intracellular Membrane-bounded Organelle Postsynaptic Membrane Mitotic Spindle Midzone	P-body Nuclear Envelope Transcription Factor Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Sarcoplasmic Reticulum Lamellipodium Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Actin Filament Binding	Protein Binding Interleukin-1 Binding Protein N-terminus Binding
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of Axon Extension Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Dendritic Spine Morphogenesis Membrane Organization Dendritic Spine Maintenance Lamellipodium Organization Postsynaptic Actin Cytoskeleton Organization Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis
Drugs
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS			Bipolar disorder ( 31043756) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010)
Interacting Genes		39 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 KEAP1 MET MYLK SDC3 SHANK2 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 WASL WIPF1	26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL UBAP2L YWHAQ ZNF420 ZNRD1
Entrez ID		2017	10456
HPRD ID		01268	12075
Ensembl ID		ENSG00000085733	ENSG00000143575
Uniprot IDs		A0A024R5M3 Q14247 Q53HG7	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs		1X69 2D1X
Enriched GO Terms of Interacting Partners?
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