SPRED2 and TOP3B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SPRED2	TOP3B
Description		sprouty related EVH1 domain containing 2	DNA topoisomerase III beta
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Transport Vesicle Membrane	Condensed Chromosome Nucleus
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I Activity Protein Binding
	Biological Process	Inactivation Of MAPK Activity Multicellular Organism Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation	DNA Topological Change Chromosome Segregation
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
GWAS		Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Gamma glutamyl transferase levels ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 27569725 23128233) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 27863252)	Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)
Interacting Genes		7 interacting genes: CTSD KIT MTDH RHOA SPG21 TOP3B ZDHHC17	18 interacting genes: ADAMTSL4 C1QBP CENPF CHD8 CHIC2 FBLN5 GRN KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF408
Entrez ID		200734	8940
HPRD ID		18100	04662
Ensembl ID		ENSG00000198369	ENSG00000100038
Uniprot IDs		B3KPL5 Q7Z698	A0A024R1C2 A8K4N2 O95985
PDB IDs		2JP2	5GVC 5GVE
Enriched GO Terms of Interacting Partners?
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