SPRED2 and SPG21

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SPRED2	SPG21
Description		sprouty related EVH1 domain containing 2	SPG21 abhydrolase domain containing, maspardin
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Transport Vesicle Membrane	Golgi Apparatus Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	Protein Binding CD4 Receptor Binding
	Biological Process	Inactivation Of MAPK Activity Multicellular Organism Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation	Antigen Receptor-mediated Signaling Pathway
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Gamma glutamyl transferase levels ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 27569725 23128233) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 27863252)
Interacting Genes		7 interacting genes: CTSD KIT MTDH RHOA SPG21 TOP3B ZDHHC17	37 interacting genes: AGTRAP AKIRIN2 ARL6IP1 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 LMNA MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263
Entrez ID		200734	51324
HPRD ID		18100	10492
Ensembl ID		ENSG00000198369	ENSG00000090487
Uniprot IDs		B3KPL5 Q7Z698	A0A024R5Y1 Q9NZD8
PDB IDs		2JP2
Enriched GO Terms of Interacting Partners?
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