ELAVL1 and HNRNPK

Number of citations of the paper that reports this interaction (PubMedID 22365833)
132

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ELAVL1	HNRNPK
Description		ELAV like RNA binding protein 1	heterogeneous nuclear ribonucleoprotein K
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Nuclear Chromatin Podosome Nucleus Nucleoplasm Cytoplasm Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding AU-rich Element Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Single-stranded DNA Binding RNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Cadherin Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Import Into Nucleus Regulation Of MRNA Stability Positive Regulation Of Translation MRNA Stabilization Protein Homooligomerization Negative Regulation Of Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance	MRNA Splicing, Via Spliceosome RNA Processing Signal Transduction Regulation Of Low-density Lipoprotein Particle Clearance Viral Process RNA Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		HuR (ELAVL1) binds and stabilizes mRNA mRNA Splicing - Major Pathway	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events
Drugs			Artenimol Phenethyl Isothiocyanate
Diseases
GWAS		Blood protein levels ( 28240269)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		37 interacting genes: ANP32A ANP32B APOE C12orf75 CARM1 CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SREK1 TNPO1 TNPO2 VCP VEGFA XIAP	115 interacting genes: ABI2 APBB1 AQP5 AURKA BTRC C6orf226 CBLB CCAR1 CCDC33 CDKN1A CEBPB CIRBP CMTM5 CNNM3 CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 EIF3F ELAVL1 FBXL18 FBXO7 FBXW7 FYN GFI1B GRAP2 GRB2 GZMA GZMK H3-4 HCK HMGB1 HNRNPA0 HNRNPD HNRNPL HNRNPLL ITK ITSN2 KHDRBS1 KHDRBS2 KHDRBS3 LYN MAPK10 MARK4 MATR3 MDM2 NCK2 NEDD4 NPDC1 PABPC1 PCBP1 PCBP2 PCDHB14 PCGF3 PELI2 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A PRR3 QKI RALY RASD1 RBFOX2 RBM10 RBM14 RBM3 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RNA18SN5 RNA28SN5 RTP5 SAFB SF1 SMAD3 SNRPA SORBS3 SPG7 SRC SREK1 SRPK2 SRRT SRSF3 SUMO1 SUMO2 SYNCRIP TBP TCERG1 TERF2IP TYK2 U2AF1 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 YWHAQ ZFC3H1 ZNF385C ZNF688 ZNF792 ZNRF2P1
Entrez ID		1994	3190
HPRD ID		16025	02834
Ensembl ID		ENSG00000066044	ENSG00000165119
Uniprot IDs		Q15717	B4DUQ1 P61978
PDB IDs		3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3	1J5K 1KHM 1ZZI 1ZZJ 1ZZK
Enriched GO Terms of Interacting Partners?
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