HNRNPK and PRKCD

Number of citations of the paper that reports this interaction (PubMedID 10329716)
35

Data Source:
HPRD (in vitro)

		HNRNPK	PRKCD
Description		heterogeneous nuclear ribonucleoprotein K	protein kinase C delta
Image
GO Annotations	Cellular Component	Nuclear Chromatin Podosome Nucleus Nucleoplasm Cytoplasm Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Nuclear Matrix Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Single-stranded DNA Binding RNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Cadherin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Insulin Receptor Substrate Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Processing Signal Transduction Regulation Of Low-density Lipoprotein Particle Clearance Viral Process RNA Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Signaling Receptor Activity Immunoglobulin Mediated Immune Response Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Termination Of Signal Transduction Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Binding Activation Of Protein Kinase Activity Interleukin-10 Production Interleukin-12 Production Positive Regulation Of Superoxide Anion Generation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Regulation Of MRNA Stability Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Filopodium Assembly Cell Chemotaxis Interferon-gamma-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Hydroperoxide Negative Regulation Of Platelet Aggregation Cellular Senescence Positive Regulation Of Phospholipid Scramblase Activity Cellular Response To Angiotensin Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events	Apoptotic cleavage of cellular proteins Calmodulin induced events Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events HuR (ELAVL1) binds and stabilizes mRNA VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Interferon gamma signaling
Drugs		Artenimol Phenethyl Isothiocyanate	Tamoxifen 13-Acetylphorbol Ingenol Mebutate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Bipolar disorder ( 21926972) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Ulcerative colitis ( 23128233) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		115 interacting genes: ABI2 APBB1 AQP5 AURKA BTRC C6orf226 CBLB CCAR1 CCDC33 CDKN1A CEBPB CIRBP CMTM5 CNNM3 CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 EIF3F ELAVL1 FBXL18 FBXO7 FBXW7 FYN GFI1B GRAP2 GRB2 GZMA GZMK H3-4 HCK HMGB1 HNRNPA0 HNRNPD HNRNPL HNRNPLL ITK ITSN2 KHDRBS1 KHDRBS2 KHDRBS3 LYN MAPK10 MARK4 MATR3 MDM2 NCK2 NEDD4 NPDC1 PABPC1 PCBP1 PCBP2 PCDHB14 PCGF3 PELI2 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A PRR3 QKI RALY RASD1 RBFOX2 RBM10 RBM14 RBM3 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RNA18SN5 RNA28SN5 RTP5 SAFB SF1 SMAD3 SNRPA SORBS3 SPG7 SRC SREK1 SRPK2 SRRT SRSF3 SUMO1 SUMO2 SYNCRIP TBP TCERG1 TERF2IP TYK2 U2AF1 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 YWHAQ ZFC3H1 ZNF385C ZNF688 ZNF792 ZNRF2P1	120 interacting genes: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GRK2 GRM5 GSK3A H1-1 H1-5 HABP4 HDAC5 HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NOTCH1 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RACK1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SPRY2 SQSTM1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP YWHAB YWHAG YWHAZ
Entrez ID		3190	5580
HPRD ID		02834	01501
Ensembl ID		ENSG00000165119	ENSG00000163932
Uniprot IDs		B4DUQ1 P61978	A0A024R328 B4DFV1 Q05655
PDB IDs		1J5K 1KHM 1ZZI 1ZZJ 1ZZK	1YRK 2YUU
Enriched GO Terms of Interacting Partners?
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