DVL2 and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		DVL2	KLHL12
Description		dishevelled segment polarity protein 2	kelch like family member 12
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome Lateral Plasma Membrane Nuclear Body Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	Frizzled Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Protein Self-association Rac GTPase Binding	Protein Binding Identical Protein Binding
	Biological Process	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription By RNA Polymerase II Segment Specification Heart Development Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Neuron Projection Arborization Beta-catenin Destruction Complex Disassembly	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Degradation of DVL
Drugs
Diseases
GWAS		Metabolite levels ( 31628463) Metabolite levels (small molecules and protein measures) ( 27005778)
Interacting Genes		102 interacting genes: ABL1 AKAP9 AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 BCL6 BEND7 BYSL CARD9 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DCUN1D1 DDI1 DPPA2 DYNLT1 EIF1B ELOA2 ENKD1 FAM161A FAM90A1 FZD4 GABARAP GABARAPL1 GMCL2 GOLGA2 GRAP2 GRB2 HIP1 IHO1 KLHL12 LMO3 LRRK2 MAGOHB MAP1LC3A MCRS1 NOL12 NUP62CL NUP88 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PPP1R16B PRKAA1 PRKCA PRKCB PRKCG PRPF3 PRPF31 PSMF1 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 RUSC1 SCNM1 SMURF1 SNF8 SNIP1 SORBS3 SSX2IP TAB1 TDP2 THAP1 TIFA TLE5 TP53 TPM3 TRAF2 U2AF2 UBAC1 UIMC1 USP5 VANGL1 VHL WAS WT1 YES1 ZBTB48 ZBTB8A ZGPAT ZNF165 ZNF250 ZNF263 ZNF410 ZNF581	46 interacting genes: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL2 DVL3 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 MTNR1A NDC80 NTAQ1 PDGFRB PEA15 PEF1 PRR13 RIT1 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 ZBP1
Entrez ID		1856	59349
HPRD ID		03690	13925
Ensembl ID		ENSG00000004975	ENSG00000117153
Uniprot IDs		O14641	Q53G59 Q9H7R2
PDB IDs		2REY 3CBX 3CBY 3CBZ 3CC0 4WIP 5LNP 5SUY 5SUZ 6IW3	2VPJ
Enriched GO Terms of Interacting Partners?
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