DUSP3 and MAPK3

Number of citations of the paper that reports this interaction (PubMedID 10224087)
28

Data Source:
HPRD (in vivo, in vitro)

		DUSP3	MAPK3
Description		dual specificity phosphatase 3	mitogen-activated protein kinase 3
Image
GO Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytosol	Cell Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Pseudopodium Protein-containing Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Tyrosine Kinase Binding	Phosphotyrosine Residue Binding MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Phosphatase Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	Inactivation Of MAPK Activity Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine Secretion Involved In Immune Response Transcription Initiation From RNA Polymerase I Promoter Protein Phosphorylation Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Cell Surface Receptor Signaling Pathway Axon Guidance Aging Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Phosphorylation Peptidyl-serine Phosphorylation Sensory Perception Of Pain Arachidonic Acid Metabolic Process Platelet Activation Regulation Of Ossification BMP Signaling Pathway Regulation Of Cellular PH Thyroid Gland Development Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Histone Phosphorylation Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Outer Ear Morphogenesis Response To Exogenous DsRNA Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Decidualization Thymus Development Regulation Of DNA-binding Transcription Factor Activity Cartilage Development Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Positive Regulation Of Telomerase Activity Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Cardiac Neural Crest Cell Development Involved In Heart Development Protein-containing Complex Assembly ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Response To Epidermal Growth Factor Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Organic Substance Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Regulation Of Cellular Response To Heat Cellular Response To Dopamine Positive Regulation Of Telomere Capping Positive Regulation Of Xenophagy Positive Regulation Of Metallopeptidase Activity Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Apolipoprotein Binding
Pathways		ERKs are inactivated	MAPK3 (ERK1) activation RAF-independent MAPK1/3 activation ISG15 antiviral mechanism Spry regulation of FGF signaling Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RNA Polymerase I Promoter Opening Signal attenuation Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants FCGR3A-mediated phagocytosis Growth hormone receptor signaling
Drugs			Sulindac Arsenic trioxide Purvalanol 5-iodotubercidin Ulixertinib
Diseases
GWAS		Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) Metabolite levels ( 23823483) Triglycerides ( 25961943)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Hodgkin's lymphoma ( 30194254) Multiple sclerosis ( 31604244 24076602) Pubertal anthropometrics ( 23449627) Schizophrenia ( 28991256 25056061 29483656) Tonsillectomy ( 27182965 28928442) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		14 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 NEUROD1 PDGFA STAT1 SYK ZAP70	171 interacting genes: AKR1C1 AMOT ARRB1 ATP1A1 BCL2 BCL3 BTBD10 C1QBP CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CDC45 CEBPB CPXM1 CREBBP CREM CRP CUEDC2 DAPK1 DCC DCP1A DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FBXW7 FCGR2B FKBP2 FOS FOXP2 FRS2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GRK2 GTF2I HDAC4 HDAC6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR IRS1 ITGAV ITGB3 JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LYN MAFG MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MAPT MBP METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NTRK1 NTRK3 NUP153 NUP58 PAK2 PDE6G PEA15 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SOS1 SOX2 SP1 SPIB SREBF1 SREBF2 STAR STAT3 STAT5A STMN1 STMN2 STUB1 SULT4A1 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TRIM54 TSC2 TTYH3 UBE4B UBTF USP21 VDR VPS52 ZC3HC1 ZNF219 ZNF7
Entrez ID		1845	5595
HPRD ID		02553	03479
Ensembl ID		ENSG00000108861	ENSG00000102882
Uniprot IDs		P51452	L7RXH5 P27361 Q9BWJ1
PDB IDs		1J4X 1VHR 3F81	2ZOQ 4QTB 6GES
Enriched GO Terms of Interacting Partners?
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