DIAPH1 and GAS7

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (pull down)

		DIAPH1	GAS7
Description		diaphanous related formin 1	growth arrest specific 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Secretory Granule Membrane Ruffle Membrane Mitotic Spindle Ficolin-1-rich Granule Membrane	Cytoplasm Cytoskeleton Plasma Membrane
	Molecular Function	RNA Binding Actin Binding Signaling Receptor Binding Protein Binding Rho GTPase Binding Ion Channel Binding	DNA-binding Transcription Factor Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Cell Migration Regulation Of Microtubule-based Process Protein Localization To Microtubule Neutrophil Degranulation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytoskeleton Organization Cellular Response To Histamine Regulation Of Cell Motility	Regulation Of Transcription, DNA-templated Cell Cycle Arrest Neuron Differentiation Neuron Projection Morphogenesis
Pathways		RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Mean platelet volume ( 27863252)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glaucoma ( 30104761 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 25173106 24002674 22570627 31798171 29785010 31959993 30054594 28073927 29235454) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		16 interacting genes: APBB1 BAIAP2 CDC7 CENPA GAS7 NEDD4 PAX6 PKD2 PRPF40A PTPRF RAC1 RHOA RHOC TCERG1 WBP4 XPO6	20 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 NCKAP1 NCKAP1L NTAQ1 PACSIN1 RPLP0 SF1 SF3A1 SFPQ WASF2
Entrez ID		1729	8522
HPRD ID		03670	16011
Ensembl ID		ENSG00000131504	ENSG00000007237
Uniprot IDs		A0A2R8Y5N1 O60610 Q6URC4	O60861
PDB IDs			2LX7 2YSH
Enriched GO Terms of Interacting Partners?
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