DDX5 and HNRNPK

Number of citations of the paper that reports this interaction (PubMedID 22365833)
132

Data Source:
BioGRID (two hybrid)

		DDX5	HNRNPK
Description		DEAD-box helicase 5	heterogeneous nuclear ribonucleoprotein K
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nuclear Chromatin Podosome Nucleus Nucleoplasm Cytoplasm Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding RNA Helicase Activity MRNA 3'-UTR Binding Protein Binding Calmodulin Binding ATP Binding Enzyme Binding MH2 Domain Binding Pre-mRNA Binding Ribonucleoprotein Complex Binding SMAD Binding Calcium-dependent Protein Binding Androgen Receptor Binding R-SMAD Binding Primary MiRNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Single-stranded DNA Binding RNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Transcription By RNA Polymerase II MRNA Transcription BMP Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Viral Genome Replication Myoblast Differentiation Regulation Of Osteoblast Differentiation Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway Pri-miRNA Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Skeletal Muscle Cell Differentiation	MRNA Splicing, Via Spliceosome RNA Processing Signal Transduction Regulation Of Low-density Lipoprotein Particle Clearance Viral Process RNA Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events
Drugs			Artenimol Phenethyl Isothiocyanate
Diseases		Prostate cancer
GWAS		Lung function (FVC) ( 30804560)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		35 interacting genes: AKAP8 CALM1 CREBBP DDX17 DHX9 EP300 ESR1 FBL FRS3 HNRNPA0 HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS1 MAPKAPK2 NCOA1 NCOA2 NCOA3 NDRG1 PIAS1 PIK3CA PIN1 PRKCA PSMA3 RBFOX2 RBM10 RBM4 SMAD3 SP1 TNNT1 TP53 UBE2I WBP11	115 interacting genes: ABI2 APBB1 AQP5 AURKA BTRC C6orf226 CBLB CCAR1 CCDC33 CDKN1A CEBPB CIRBP CMTM5 CNNM3 CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 EIF3F ELAVL1 FBXL18 FBXO7 FBXW7 FYN GFI1B GRAP2 GRB2 GZMA GZMK H3-4 HCK HMGB1 HNRNPA0 HNRNPD HNRNPL HNRNPLL ITK ITSN2 KHDRBS1 KHDRBS2 KHDRBS3 LYN MAPK10 MARK4 MATR3 MDM2 NCK2 NEDD4 NPDC1 PABPC1 PCBP1 PCBP2 PCDHB14 PCGF3 PELI2 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A PRR3 QKI RALY RASD1 RBFOX2 RBM10 RBM14 RBM3 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RNA18SN5 RNA28SN5 RTP5 SAFB SF1 SMAD3 SNRPA SORBS3 SPG7 SRC SREK1 SRPK2 SRRT SRSF3 SUMO1 SUMO2 SYNCRIP TBP TCERG1 TERF2IP TYK2 U2AF1 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 YWHAQ ZFC3H1 ZNF385C ZNF688 ZNF792 ZNRF2P1
Entrez ID		1655	3190
HPRD ID		01615	02834
Ensembl ID		ENSG00000108654	ENSG00000165119
Uniprot IDs		J3KTA4 P17844	B4DUQ1 P61978
PDB IDs		3FE2 4A4D	1J5K 1KHM 1ZZI 1ZZJ 1ZZK
Enriched GO Terms of Interacting Partners?
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