AP2A1 and NUMB

Number of citations of the paper that reports this interaction (PubMedID 12942088)
83

Data Source:
HPRD (in vivo)

		AP2A1	NUMB
Description		adaptor related protein complex 2 subunit alpha 1	NUMB endocytic adaptor protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Endolysosome Membrane Clathrin-coated Endocytic Vesicle	Nucleus Cytoplasm Early Endosome Plasma Membrane Focal Adhesion Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Positive Regulation Of Neuron Projection Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Ephrin Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance	Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state
Drugs
Diseases
GWAS			Bipolar disorder with mood-incongruent psychosis ( 23092984) Coronary artery calcification ( 17903303) Macular thickness ( 30535121) Multisite chronic pain ( 31194737)
Interacting Genes		26 interacting genes: AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC	33 interacting genes: AP2A1 AP2A2 APP DNAJC5 DPYSL2 EGFR EPS15 FBXO7 FRS3 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 OLIG1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 TERF2
Entrez ID		160	8650
HPRD ID		03016	04767
Ensembl ID		ENSG00000196961	ENSG00000133961
Uniprot IDs		O95782	A0A024R681 A0A024R684 A0A024R6C4 A0A024R6F4 P49757
PDB IDs			5NJJ 5NJK
Enriched GO Terms of Interacting Partners?
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