HSPG2 and NID2

Number of citations of the paper that reports this interaction (PubMedID 9733643)
69

Data Source:
HPRD (in vitro)

		HSPG2	NID2
Description		heparan sulfate proteoglycan 2	nidogen 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Plasma Membrane Protein Complex	Extracellular Region Basement Membrane Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Low-density Lipoprotein Particle Receptor Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding
	Biological Process	Retinoid Metabolic Process Angiogenesis Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Brain Development Animal Organ Morphogenesis Tissue Development Negative Regulation Of Angiogenesis Cell Differentiation Extracellular Matrix Organization Cellular Protein Metabolic Process Cardiovascular System Development	Cell Adhesion Cell-matrix Adhesion Extracellular Matrix Organization Basement Membrane Organization
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation	Laminin interactions Laminin interactions
Drugs		Palifermin
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Atrial fibrillation ( 30061737) Height ( 28552196)	Blood protein levels ( 30072576 29875488) Body mass index ( 28892062) Craniofacial microsomia ( 26853712) Lung cancer (smoking interaction) ( 24658283) Pulmonary function ( 17903307) Triglyceride levels ( 29403010) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		31 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TTR UBC VWA1	8 interacting genes: COL13A1 COL1A1 COL4A1 ELN HSPG2 KRTAP10-3 LAMC1 SKIL
Entrez ID		3339	22795
HPRD ID		00804	05654
Ensembl ID		ENSG00000142798	ENSG00000087303
Uniprot IDs		P98160	Q14112
PDB IDs		3SH4 3SH5
Enriched GO Terms of Interacting Partners?
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