CTBP2 and ZBP1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (pull down)

		CTBP2	ZBP1
Description		C-terminal binding protein 2	Z-DNA binding protein 1
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GO Annotations	Cellular Component	Nucleus Transcriptional Repressor Complex Cell Junction Photoreceptor Ribbon Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse Presynaptic Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Retinoic Acid Receptor Binding Protein-containing Complex Binding NAD Binding Structural Constituent Of Presynaptic Active Zone	DNA Binding Left-handed Z-DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Cell Proliferation Synaptic Vesicle Docking Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Maintenance Of Presynaptic Active Zone Structure White Fat Cell Differentiation Oxidation-reduction Process Cellular Response To Leukemia Inhibitory Factor	Biological_process Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Repression of WNT target genes TCF7L2 mutants don't bind CTBP	ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN RIP-mediated NFkB activation via ZBP1 Regulation of innate immune responses to cytosolic DNA
Drugs
Diseases
GWAS		Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Body mass index ( 25673413 29273807) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Height ( 25429064) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Prostate cancer ( 18264096) Vigorous physical activity ( 29899525)	Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075) Verbal declarative memory ( 25648963)
Interacting Genes		67 interacting genes: ACTG1 AKTIP APP ATE1 BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 H3-4 HIC1 HOXB5 IKZF2 KCNIP3 KLF3 KLF8 MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBC UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750	8 interacting genes: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6
Entrez ID		1488	81030
HPRD ID		04016	09484
Ensembl ID		ENSG00000175029	ENSG00000124256
Uniprot IDs		P56545	Q9H171
PDB IDs		2OME 4LCJ	2L4M 2LNB 3EYI 4KA4
Enriched GO Terms of Interacting Partners?
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