CSTB and CTSB

Number of citations of the paper that reports this interaction (PubMedID 26208400)
5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		CSTB	CTSB
Description		cystatin B	cathepsin B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Intracellular Nucleolus Lysosome External Side Of Plasma Membrane Endolysosome Lumen Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity	Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Negative Regulation Of Proteolysis	Toll-like Receptor Signaling Pathway Proteolysis Thyroid Hormone Generation Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Neutrophil Degranulation Decidualization Viral Entry Into Host Cell Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Neutrophil degranulation	Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation
Drugs		Cupric Chloride	2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic Acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}- N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)	Tropical calcific pancreatitis
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Blood protein levels ( 30072576 29875488 28240269) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 28892059) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Triglyceride levels ( 29083408) Triglycerides ( 30275531)
Interacting Genes		9 interacting genes: COL6A1 CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2	36 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD FAM118B HNRNPD HSPB2 IGF1 INS MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1
Entrez ID		1476	1508
HPRD ID		03091	00287
Ensembl ID		ENSG00000160213	ENSG00000164733
Uniprot IDs		P04080 Q76LA1	A0A024R374 B4DMY4 P07858 Q5HYG5
PDB IDs		1STF 2OCT 4N6V	1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?