ZNF688 and RFX6

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		ZNF688	RFX6
Description		zinc finger protein 688	regulatory factor X6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Nuclear Chromatin Nucleus
	Molecular Function	Molecular_function DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Biological_process	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation
Pathways		Generic Transcription Pathway	Regulation of gene expression in beta cells
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease ( 30804561) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 27841878) Height ( 31562340) Inflammatory bowel disease ( 27569725) Lung cancer ( 28604730) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Prostate cancer ( 20676098 31562322 26443449) Serum total protein level ( 29403010)
Interacting Genes		70 interacting genes: ABI2 BEND5 BLZF1 CADPS CALCOCO2 CARD9 CBY2 CCDC136 CCDC33 CCDC57 CEP44 CEP70 CEP72 CRX EHMT2 FBXO7 FCHO1 FHL5 GMPPA GOLGA2 GPRASP2 HMBOX1 HNRNPK HOMEZ IHO1 KHDRBS2 KHDRBS3 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-9 KRTAP12-2 KRTAP4-2 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MKRN3 NOTCH2NLA PCBD1 PLSCR1 PNMA1 PNMA2 PSMA3 PSTPIP1 REL RFX6 RINT1 RPGRIP1 SPAG5 SSX2IP TADA2A TCF12 TCF4 TMCC2 TNS2 TRAF1 TRAF2 TRAF4 TRIM23 TRIM27 TRIP6 USHBP1 WWP2 ZC4H2	27 interacting genes: ARNT2 CATSPER1 CCNK CYFIP1 DGCR6 DTX2 ESR2 FHL3 FRS3 HGS KIF1A LMO3 NEDD9 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 TLE5 VPS37C ZNF688
Entrez ID		146542	222546
HPRD ID		14070	11490
Ensembl ID		ENSG00000229809	ENSG00000185002
Uniprot IDs		A0A024QZB6 A0A0S2Z633 P0C7X2	Q8HWS3
PDB IDs
Enriched GO Terms of Interacting Partners?
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