CSN2 and NFYC

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		CSN2	NFYC
Description		casein beta	nuclear transcription factor Y subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nuclear Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Enzyme Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Calcium Ion Transport Lactation Negative Regulation Of Lactation Negative Regulation Of Cysteine-type Endopeptidase Activity	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Folding Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nuclear signaling by ERBB4	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS			Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926) Depressive and manic episodes in bipolar disorder ( 26297903) Platelet count ( 21507922)
Interacting Genes		17 interacting genes: AURKA CDC42 CDK1 CELA1 CSN3 CSNK2A1 CSNK2B FHL2 GRB2 HTRA2 NEK1 NEK2 NEK9 NFYC PLK1 RAC1 TOLLIP	26 interacting genes: ADNP2 ARID2 ATF6 ATF6B BICRA BICRAL CIC CSN2 DST GAPDH LMO4 MYC NFYA NFYB POGZ SMAD2 SMAD3 SNX2 SP1 SREBF2 TAF11 TAF12 TAF6 TBP USF3 ZDHHC17
Entrez ID		1447	4802
HPRD ID		00281	05633
Ensembl ID		ENSG00000135222	ENSG00000066136
Uniprot IDs		P05814 W5RWE1	Q13952
PDB IDs			1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS
Enriched GO Terms of Interacting Partners?
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