DUSP19 and ROR1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		DUSP19	ROR1
Description		dual specificity phosphatase 19	receptor tyrosine kinase like orphan receptor 1
Image
GO Annotations	Cellular Component	Cytoplasm	Stress Fiber Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Axon Terminus
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Phosphatase Activity Protein Kinase Activator Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Negative Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Peptidyl-tyrosine Dephosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Inner Ear Development Anatomical Structure Development Positive Regulation Of NF-kappaB Transcription Factor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of ERK1 And ERK2 Cascade
Pathways			WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817)
Interacting Genes		18 interacting genes: ALK EGFR EPHA2 EPHB6 ERBB2 ERBB3 ERBB4 FLT4 IGF1R INSR KDR LMTK2 MAP2K7 MAP3K5 MAPK9 PTK7 ROR1 ROR2	13 interacting genes: APP DUPD1 DUSP14 DUSP18 DUSP19 DUSP21 ILKAP MFHAS1 PPM1B PPM1F PTPN6 PTPRR STYX
Entrez ID		142679	4919
HPRD ID		13254	03821
Ensembl ID		ENSG00000162999	ENSG00000185483
Uniprot IDs		Q8WTR2	Q01973
PDB IDs		3S4E 4D3P 4D3Q 4D3R	5Z55 6BA5 6BAN
Enriched GO Terms of Interacting Partners?
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