ROR1 and PTPRR

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		ROR1	PTPRR
Description		receptor tyrosine kinase like orphan receptor 1	protein tyrosine phosphatase receptor type R
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Axon Terminus	Extracellular Space Cytosol Plasma Membrane Integral Component Of Membrane Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Inner Ear Development Anatomical Structure Development Positive Regulation Of NF-kappaB Transcription Factor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of ERK1 And ERK2 Cascade	In Utero Embryonic Development Protein Dephosphorylation Negative Regulation Of Epithelial Cell Migration Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion
Pathways		WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817)	Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Influenza A (H1N1) infection ( 26379185) Intraocular pressure ( 29785010) Mild influenza (H1N1) infection ( 26379185) Monobrow ( 27182965) Refractive error ( 23396134) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Uterine fibroids ( 31649266)
Interacting Genes		13 interacting genes: APP DUPD1 DUSP14 DUSP18 DUSP19 DUSP21 ILKAP MFHAS1 PPM1B PPM1F PTPN6 PTPRR STYX	24 interacting genes: AATK EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 IGF1R INSR KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK TEK
Entrez ID		4919	5801
HPRD ID		03821	04169
Ensembl ID		ENSG00000185483	ENSG00000153233
Uniprot IDs		Q01973	Q15256 Q7Z2V8
PDB IDs		5Z55 6BA5 6BAN	2A8B
Enriched GO Terms of Interacting Partners?
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