SIRPA and COL6A2

Number of citations of the paper that reports this interaction (PubMedID 19299420)
12

Data Source:
BioGRID (pull down)

		SIRPA	COL6A2
Description		signal regulatory protein alpha	collagen type VI alpha 2 chain
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex Sarcolemma Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding	Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Negative Regulation Of Protein Phosphorylation Cell Adhesion Regulation Of Gene Expression Cell Migration Positive Regulation Of Cell-cell Adhesion Regulation Of Interferon-gamma Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Neutrophil Degranulation Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Regulation Of Catalytic Activity Positive Regulation Of T Cell Activation Leukocyte Migration Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of I-kappaB Phosphorylation	Growth Plate Cartilage Chondrocyte Morphogenesis Cell Adhesion Response To Glucose Extracellular Matrix Organization
Pathways		Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases			Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576 29875488) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 22139419 19820697 27863252) Platelet count ( 29403010)	Central corneal thickness ( 29760442) Height ( 31562340) Intraocular pressure ( 29235454)
Interacting Genes		57 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 EIF5B ELOA FBN2 FLNA FTH1 FUBP1 GNL1 HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM27 VIM	6 interacting genes: ABCD3 COL6A1 COX6A2 FN1 SIRPA SLC38A3
Entrez ID		140885	1292
HPRD ID		03912	02110
Ensembl ID		ENSG00000198053	ENSG00000142173
Uniprot IDs		P78324	A0A384MDP3 P12110
PDB IDs		2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV
Enriched GO Terms of Interacting Partners?
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