SIRPA and NUCB1

Number of citations of the paper that reports this interaction (PubMedID 19299420)
12

Data Source:
BioGRID (pull down)

		SIRPA	NUCB1
Description		signal regulatory protein alpha	nucleobindin 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi-associated Vesicle Cis-Golgi Network Trans-Golgi Network Membrane Golgi Cisterna Membrane Extracellular Exosome Extrinsic Component Of Golgi Membrane Lumenal Side Of Golgi Membrane
	Molecular Function	SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cell Adhesion Regulation Of Gene Expression Cell Migration Positive Regulation Of Cell-cell Adhesion Regulation Of Interferon-gamma Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Neutrophil Degranulation Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Regulation Of Catalytic Activity Positive Regulation Of T Cell Activation Leukocyte Migration Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of I-kappaB Phosphorylation	Small GTPase Mediated Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process Response To Cisplatin Regulation Of Protein Targeting
Pathways		Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Calcium Citrate Calcium Phosphate
Diseases
GWAS		Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576 29875488) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 22139419 19820697 27863252) Platelet count ( 29403010)
Interacting Genes		57 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 EIF5B ELOA FBN2 FLNA FTH1 FUBP1 GNL1 HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM27 VIM	17 interacting genes: GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 MYC NDN PLOD2 PTGS1 PTGS2 RBL1 REL SET SIRPA XPO1
Entrez ID		140885	4924
HPRD ID		03912	03205
Ensembl ID		ENSG00000198053	ENSG00000104805
Uniprot IDs		P78324	A8K7Q1 Q02818
PDB IDs		2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV	1SNL
Enriched GO Terms of Interacting Partners?
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