SGF29 and NDC80

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SGF29	NDC80
Description		SAGA complex associated factor 29	NDC80 kinetochore complex component
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GO Annotations	Cellular Component	SAGA Complex Ada2/Gcn5/Ada3 Transcription Activator Complex SAGA-type Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding Methylated Histone Binding Protein N-terminus Binding	Protein Binding Identical Protein Binding
	Biological Process	Histone Acetylation Histone H3 Acetylation RNA Polymerase II Preinitiation Complex Assembly Establishment Of Protein Localization To Chromatin	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore
Pathways		HATs acetylate histones	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		11 interacting genes: CCDC102B CCDC158 CLHC1 H3-4 KRT13 KRT15 LNX1 MED4 NDC80 RINT1 TADA3	46 interacting genes: AMOTL2 ATF4 ATP5PO AURKA AURKB BLOC1S6 CALCOCO1 CCHCR1 CCNH CCNK CENPH CKAP5 HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 WASHC3 ZWINT
Entrez ID		112869	10403
HPRD ID		13996	06277
Ensembl ID		ENSG00000176476	ENSG00000080986
Uniprot IDs		Q96ES7	A8K031 O14777
PDB IDs		3LX7 3ME9 3MEA 3MET 3MEU 3MEV 3MEW 5C0M	2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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