CHD4 and PSTPIP1

Number of citations of the paper that reports this interaction (PubMedID 29907651)
14

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CHD4	PSTPIP1
Description		chromodomain helicase DNA binding protein 4	proline-serine-threonine phosphatase interacting protein 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein-containing Complex	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding	Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Heel bone mineral density ( 30598549) Myopia (pathological) ( 23049088)	Neurofibrillary tangles ( 31497858)
Interacting Genes		19 interacting genes: ATM ATR CSNK2A1 EP300 H3-4 H3C1 HDAC1 IKZF4 MBD3L2 MTNR1A PSTPIP1 RNF8 RORC SMARCA4 SUMO2 TRIM27 TWIST1 UBE2I XRN1	42 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 DNM2 EXOC5 FAM90A1 FASLG FBXL18 HMG20A KHDRBS1 LSM4 MEFV MFGE8 MVP NAV2 PCDHB14 PRPF31 PTPN12 PTPN18 RINT1 RTP5 RXRB SDCBP SH2D4A SHBG SPG7 SYCE1 TFIP11 TRAF3IP3 TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175 ZNF688
Entrez ID		1108	9051
HPRD ID		04472	05891
Ensembl ID		ENSG00000111642	ENSG00000140368
Uniprot IDs		F5GWX5 Q14839	A0A0S2Z5P3 O43586
PDB IDs		1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG	2DIL
Enriched GO Terms of Interacting Partners?
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