HSF2BP and CDC73

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		HSF2BP	CDC73
Description		heat shock transcription factor 2 binding protein	cell division cycle 73
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex
	Molecular Function	Protein Binding	RNA Polymerase II Complex Binding Protein Binding
	Biological Process	Transcription By RNA Polymerase II Spermatogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Proliferation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Beta-catenin-TCF Complex Assembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases			Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Eosinophilic esophagitis ( 25017104) Mean corpuscular volume ( 27863252) Plasma anti-thyroid peroxidase levels ( 29678681) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 30578418)	Chronotype ( 30696823) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)
Interacting Genes		4 interacting genes: CDC73 HSF2 UBE2I UPF2	30 interacting genes: ALAS1 ANXA6 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PITHD1 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TSGA10 VPS37B WWC1
Entrez ID		11077	79577
HPRD ID		05186	09581
Ensembl ID		ENSG00000160207	ENSG00000134371
Uniprot IDs		O75031 Q6IAT7	Q6P1J9
PDB IDs			5YDE 5YDF
Enriched GO Terms of Interacting Partners?
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