NFAT5 and TBC1D4

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		NFAT5	TBC1D4
Description		nuclear factor of activated T cells 5	TBC1 domain family member 4
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol Nuclear Transcription Factor Complex	Cytosol Vesicle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding	GTPase Activator Activity Protein Binding Rab GTPase Binding
	Biological Process	Cytokine Production Transcription By RNA Polymerase II Response To Osmotic Stress Signal Transduction Excretion Calcineurin-NFAT Signaling Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Intracellular Protein Transport Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus Activation Of GTPase Activity
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Blood osmolality (transformed sodium) ( 28360221) Blood urea nitrogen levels ( 31152163 29403010) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Chloride levels ( 29403010) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31015462 30604766) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Hyperuricemia ( 29124443) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 31589552) Pulse pressure ( 28135244 27841878) Self-reported risk-taking behaviour ( 30181555) Serum uric acid levels ( 30993211 29124443) SjÃ¶gren's syndrome ( 28076899) Smoking initiation (ever regular vs never regular) ( 30679032) Sodium levels ( 29403010) Type 2 diabetes ( 30054458 30297969) Urate levels ( 23263486)	Diabetic retinopathy ( 23562823) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 27863252) Mean platelet volume ( 27863252) Red blood cell count ( 29403010 27863252) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		4 interacting genes: FOXP3 NUTF2 TBC1D4 TRIM14	15 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		10725	9882
HPRD ID		05272	18164
Ensembl ID		ENSG00000102908	ENSG00000136111
Uniprot IDs		A0A024R734 O94916	A0A3B3IRT3 O60343
PDB IDs		1IMH	3QYB
Enriched GO Terms of Interacting Partners?
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