CELF1 and DMPK

Number of citations of the paper that reports this interaction (PubMedID 9371827)
48

Data Source:
HPRD (in vitro)

		CELF1	DMPK
Description		CUGBP Elav-like family member 1	DM1 protein kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Ribonucleoprotein Complex	Cell Nuclear Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Mitochondrial Outer Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding BRE Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Myosin Phosphatase Regulator Activity Metal Ion Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing Germ Cell Development Embryo Development Ending In Birth Or Egg Hatching RNA Interference Negative Regulation Of Translation Regulation Of RNA Splicing	Regulation Of Sodium Ion Transport Protein Phosphorylation Cellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Synapse Structural Plasticity Regulation Of Cardiac Conduction
Pathways			Ion homeostasis
Drugs			3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione
Diseases			Myotonic dystrophy (DM)
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body mass index ( 28552196) Estimated glomerular filtration rate ( 30604766) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Immature fraction of reticulocytes ( 27863252) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Metabolic syndrome ( 31589552) Neuroticism ( 29255261) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Sleep duration (short sleep) ( 30846698) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969)	Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)
Interacting Genes		7 interacting genes: APP DMPK FUBP1 HNRNPC PPBP RALY TOM1L1	19 interacting genes: ANXA7 ATN1 ATXN1 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A PVR RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4
Entrez ID		10658	1760
HPRD ID		03046	05645
Ensembl ID		ENSG00000149187	ENSG00000104936
Uniprot IDs		G5EA30 Q92879	B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013
PDB IDs		2CPZ 2DHS 2RQ4 2RQC 3NMR 3NNA 3NNC 3NNH	1WT6 2VD5
Enriched GO Terms of Interacting Partners?
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