SH2B1 and KIAA0319

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		SH2B1	KIAA0319
Description		SH2B adaptor protein 1	KIAA0319
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Early Endosome Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Protein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of SMAD Protein Signal Transduction Regulation Of DNA Biosynthetic Process	Neuron Migration Response To Auditory Stimulus Negative Regulation Of Axon Extension Multicellular Organismal Response To Stress Negative Regulation Of Axon Extension Involved In Regeneration Positive Regulation Of SMAD Protein Signal Transduction Membrane Organization Negative Regulation Of Dendrite Development
Pathways		Factors involved in megakaryocyte development and platelet production	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 19079260 19079261 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Mean corpuscular volume ( 27863252) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 27863252) Waist circumference ( 25673412) Weight ( 19079260)	Radiation response ( 20923822) Serum uric acid levels ( 30993211) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		13 interacting genes: CSAD EGFR FGFR3 FRS3 GRB2 IGF1R INSR JAK2 KIAA0319 NTRK1 NTRK2 RHBG SH2B2	3 interacting genes: APP FEM1B SH2B1
Entrez ID		25970	9856
HPRD ID		12336	18713
Ensembl ID		ENSG00000178188	ENSG00000137261
Uniprot IDs		A0A024QZ92 A0A024QZC2 A0A024QZD2 B3KNV5 B4DLN5 Q9NRF2	A0A087X0U9 Q5VV43
PDB IDs		5W3R	2E7M
Enriched GO Terms of Interacting Partners?
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