PATJ and PRDM16

Number of citations of the paper that reports this interaction (PubMedID 16637659)
25

Data Source:
HPRD (in vitro)

		PATJ	PRDM16
Description		PATJ crumbs cell polarity complex component	PR/SET domain 16
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytosol Aggresome Transcriptional Repressor Complex
	Molecular Function	Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Activating Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process	Intracellular Signal Transduction Bicellular Tight Junction Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Neurogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Regulation Of Cellular Respiration Tongue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Brown Fat Cell Differentiation Histone H3-K9 Methylation Roof Of Mouth Development Heterochromatin Organization Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)	Allergic rhinitis ( 25085501) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618448) Headache ( 29397368) Hematocrit ( 27863252) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 23793025 21666692 27322543) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Motion sickness ( 25628336) Nose morphology ( 29921221) Optic disc size ( 31809533) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) QRS duration ( 25035420) Red blood cell count ( 27863252) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30891314) Systolic blood pressure ( 27618448) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		28 interacting genes: ADGRB1 ASIC3 CACNG2 CLDN1 CNKSR2 CRB3 CRIPT DDX18 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 MPP5 NLGN2 NRXN2 PARD3 PAX6 PRDM16 SCN4A SCN5A TJP3	2 interacting genes: PATJ RBBP4
Entrez ID		10207	63976
HPRD ID		04434	16122
Ensembl ID		ENSG00000132849	ENSG00000142611
Uniprot IDs			Q9HAZ2
PDB IDs			2N1I 6BW4
Enriched GO Terms of Interacting Partners?
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