PRDM16 and RBBP4

Number of citations of the paper that reports this interaction (PubMedID 30462309)
1

Data Source:
BioGRID (affinity chromatography technology, pull down, x-ray crystallography)

		PRDM16	RBBP4
Description		PR/SET domain 16	RB binding protein 4, chromatin remodeling factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome Transcriptional Repressor Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Sin3 Complex NuRD Complex NURF Complex Protein-containing Complex CAF-1 Complex ESC/E(Z) Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Activating Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Neurogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Regulation Of Cellular Respiration Tongue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Brown Fat Cell Differentiation Histone H3-K9 Methylation Roof Of Mouth Development Heterochromatin Organization Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis	DNA Replication DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Cell Cycle Negative Regulation Of Cell Proliferation Chromatin Assembly CENP-A Containing Nucleosome Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Cycle Response To Growth Hormone Negative Regulation Of G0 To G1 Transition Regulation Of Signal Transduction By P53 Class Mediator
Pathways		PKMTs methylate histone lysines	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS		Allergic rhinitis ( 25085501) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618448) Headache ( 29397368) Hematocrit ( 27863252) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 23793025 21666692 27322543) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Motion sickness ( 25628336) Nose morphology ( 29921221) Optic disc size ( 31809533) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) QRS duration ( 25035420) Red blood cell count ( 27863252) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30891314) Systolic blood pressure ( 27618448) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		2 interacting genes: PATJ RBBP4	62 interacting genes: AEBP2 ANXA7 ARMC12 BCL11A BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP CYTOR DHX30 ESR1 FOXK2 H1-1 H2AC20 H3-4 H3C1 H3C14 H4-16 H4C14 HAT1 HDAC1 HDAC2 HDAC3 HDAC4 HMOX2 ING1 KPNA3 KPNA5 LIN37 LIN52 LIN9 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 MYBL2 NR2E3 PRDM16 RB1 RBBP7 RBP1 RPN1 RPN2 RYBP SALL4 SAP30 SIN3A SMN1 SP1 SP3 SPEN SUMO2 SUV39H1 TK1 TSSK3 XRCC6
Entrez ID		63976	5928
HPRD ID		16122	04232
Ensembl ID		ENSG00000142611	ENSG00000162521
Uniprot IDs		Q9HAZ2	Q09028
PDB IDs		2N1I 6BW4	2XU7 3GFC 4PBY 4PBZ 4PC0 4R7A 5FXY 5VTB 5WAI 5WAK 5XWR 5XXQ 5Y1U 6BW3 6BW4 6C23 6C24 6G16
Enriched GO Terms of Interacting Partners?
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