PATJ and CACNG2

Number of citations of the paper that reports this interaction (PubMedID 16637659)
25

Data Source:
HPRD (in vitro)

		PATJ	CACNG2
Description		PATJ crumbs cell polarity complex component	calcium voltage-gated channel auxiliary subunit gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cell Surface Cell Junction Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Cerebellar Mossy Fiber Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding	Voltage-gated Calcium Channel Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Intracellular Signal Transduction Bicellular Tight Junction Assembly	Protein Targeting To Membrane Neuromuscular Junction Development Transmission Of Nerve Impulse Response To Calcium Ion Membrane Depolarization Membrane Hyperpolarization Eye Blink Reflex Cardiac Conduction Calcium Ion Transmembrane Transport Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Postsynaptic Neurotransmitter Receptor Diffusion Trapping Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Basolateral Plasma Membrane Regulation Of AMPA Receptor Activity Positive Regulation Of AMPA Receptor Activity
Pathways			Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors Phase 0 - rapid depolarisation Phase 2 - plateau phase LGI-ADAM interactions
Drugs			Ethanol
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)	Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
Interacting Genes		28 interacting genes: ADGRB1 ASIC3 CACNG2 CLDN1 CNKSR2 CRB3 CRIPT DDX18 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 MPP5 NLGN2 NRXN2 PARD3 PAX6 PRDM16 SCN4A SCN5A TJP3	10 interacting genes: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 PATJ PRKACA SRPK2
Entrez ID		10207	10369
HPRD ID		04434	04220
Ensembl ID		ENSG00000132849	ENSG00000166862
Uniprot IDs			Q9Y698
PDB IDs			6DLZ 6DM0 6DM1 6O9G
Enriched GO Terms of Interacting Partners?
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