SAE1 and IL3RA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SAE1	IL3RA
Description		SUMO1 activating enzyme subunit 1	interleukin 3 receptor subunit alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity	Cytokine Receptor Activity Interleukin-3 Receptor Activity Cytokine Binding
	Biological Process	Protein Ubiquitination Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion	MAPK Cascade Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs			Sargramostim
Diseases
GWAS		Lymphocyte counts ( 27863252) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) White blood cell count ( 27863252)	Schizophrenia ( 17522711)
Interacting Genes		13 interacting genes: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39	15 interacting genes: CDC25A CDK1 CISH CSF2 CSF2RB FOXP1 GNA12 IL3 JAK1 JAK2 LNX1 NR0B2 PPP1CC SAE1 SGK2
Entrez ID		10055	3563
HPRD ID		18010	02392
Ensembl ID		ENSG00000142230	ENSG00000185291
Uniprot IDs		A0A024R0R4 Q9UBE0	P26951
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ	4JZJ 5UV8 5UWC
Enriched GO Terms of Interacting Partners?
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