IL3RA and FOXP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		IL3RA	FOXP1
Description		interleukin 3 receptor subunit alpha	forkhead box P1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Cytokine Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding Protein Binding Identical Protein Binding Protein Self-association Metal Ion Binding Androgen Receptor Binding
	Biological Process	MAPK Cascade Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Osteoclast Differentiation Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor Production Somatic Stem Cell Population Maintenance Chemokine (C-C Motif) Ligand 2 Secretion Osteoclast Development Macrophage Activation Monocyte Activation Endothelial Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway T Follicular Helper Cell Differentiation Interleukin-21 Secretion Regulation Of Defense Response To Bacterium Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of Interleukin-12 Secretion
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Sargramostim
Diseases
GWAS		Schizophrenia ( 17522711)	Adventurousness ( 30643258) Anorexia nervosa ( 31308545) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254 31527586) Basal cell carcinoma ( 31174203 27539887) Breast cancer ( 29059683) Chronotype ( 30696823) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Esophageal adenocarcinoma ( 24121790) Familial lung adenocarcinoma ( 29924316) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Height ( 28552196) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998 24002674 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lung function (FVC) ( 30804560) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 24076602) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 27863252) Non-melanoma skin cancer ( 29739929) Nose size ( 27182965) Number of sexual partners ( 30643258) Optic disc size ( 31809533) Primary sclerosing cholangitis ( 27992413) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Red blood cell count ( 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Selective IgA deficiency ( 27723758) Squamous cell carcinoma ( 26829030) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 27841878) Tooth agenesis (maxillary lateral incisors) ( 29364747) Vitiligo ( 27723757)
Interacting Genes		15 interacting genes: CDC25A CDK1 CISH CSF2 CSF2RB FOXP1 GNA12 IL3 JAK1 JAK2 LNX1 NR0B2 PPP1CC SAE1 SGK2	9 interacting genes: AURKA CTBP1 FOXP2 FOXP4 IKZF1 IL3RA LRRK1 MNAT1 NCOR2
Entrez ID		3563	27086
HPRD ID		02392	18518
Ensembl ID		ENSG00000185291	ENSG00000114861
Uniprot IDs		P26951	A0A3B3IS20 A0A3B3IT66 Q548T7 Q8N2P0 Q8TEA2 Q9H334
PDB IDs		4JZJ 5UV8 5UWC	2KIU
Enriched GO Terms of Interacting Partners?
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