SAE1

Description		SUMO1 activating enzyme subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Protein Ubiquitination Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS		Lymphocyte counts ( 27863252) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) White blood cell count ( 27863252)
Interacting Genes		13 interacting genes: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39
Entrez ID		10055
HPRD ID		18010
Ensembl ID		ENSG00000142230
Uniprot IDs		A0A024R0R4 Q9UBE0
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ
Enriched GO Terms of Interacting Partners?
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