SAE1 and ETV4

Number of citations of the paper that reports this interaction (PubMedID 19307308)
35

Data Source:
BioGRID (enzymatic study)

		SAE1	ETV4
Description		SUMO1 activating enzyme subunit 1	ETS variant transcription factor 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Protein Ubiquitination Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)	MAPK6/MAPK4 signaling
Drugs
Diseases			Ewing's sarcoma Prostate cancer
GWAS		Lymphocyte counts ( 27863252) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) White blood cell count ( 27863252)
Interacting Genes		13 interacting genes: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39	12 interacting genes: APP ATXN1 EP300 EPAS1 HIF1A HOXD4 HTT JUN SAE1 SRF STK11 UBA2
Entrez ID		10055	2118
HPRD ID		18010	02833
Ensembl ID		ENSG00000142230	ENSG00000175832
Uniprot IDs		A0A024R0R4 Q9UBE0	P43268
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ	4CO8 4UUV 5ILU
Enriched GO Terms of Interacting Partners?
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