KMT2B and NREP

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KMT2B	NREP
Gene Name		lysine (K)-specific methyltransferase 2B	neuronal regeneration related protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleus Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific)	Protein Binding
	Biological Process	Ovarian Follicle Development Chromatin Organization Transcription, DNA-templated Oocyte Differentiation Gene Silencing Ovulation Chromatin-mediated Maintenance Of Transcription Histone H3-K4 Methylation Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation	Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Regulation Of Neuron Differentiation
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		22 interactors: ANXA1 ANXA7 ATP1B1 ATXN1 CDKN1A GRB7 HIST1H3A HIST2H3C NREP PIN1 PRPF40A RAP1B RCC1 RPP14 SEPT8 SMAD3 SMARCB1 SMN1 TK1 TSC22D1 WDR5 ZNF512B	3 interactors: EEF1A1 IGSF21 KMT2B
Entrez ID		9757	9315
HPRD ID		06017	09545
Ensembl ID		ENSG00000272333	ENSG00000134986
Uniprot IDs		Q9UMN6	Q16612
PDB IDs		3UVM 4ERZ
Enriched GO Terms of Interacting Partners?		Hemostasis Response To Wounding Regulation Of Body Fluid Levels Response To Stress Wound Healing Regulation Of Mitotic Cell Cycle Blood Coagulation Nucleobase-containing Compound Metabolic Process DNA Methylation On Cytosine Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Regulation Of Metabolic Process Chromatin Silencing At RDNA Cellular Nitrogen Compound Metabolic Process Epithelial Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Cyclic Compound Gene Silencing Negative Regulation Of Gene Expression Cell Cycle Regulation Of Cell Cycle Regulation Of Cellular Component Organization Digestive Tract Development Nitrogen Compound Metabolic Process Digestive System Development Response To Abiotic Stimulus Liver Development Response To X-ray Response To Glucocorticoid Positive Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Phosphorylation Gene Expression Response To Corticosteroid Chromatin Silencing Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression, Epigenetic Neutrophil Clearance Positive Regulation Of Transforming Growth Factor Beta3 Production Fetal Process Involved In Parturition Regulation Of Cell Junction Assembly RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokinesis DNA Methylation Cellular Process Regulation Of Cell Division RNA Processing Mitotic Cell Cycle Phase Transition	Chromatin-mediated Maintenance Of Transcription Histone H3-K4 Trimethylation Positive Regulation Of Gene Expression, Epigenetic Ovulation Regulation Of Histone H3-K4 Methylation Cellular Response To Epidermal Growth Factor Stimulus Peptidyl-lysine Trimethylation Response To Epidermal Growth Factor Histone H3-K4 Methylation
Tagcloud ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2a landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased
Tagcloud (Difference) ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2a landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased
Tagcloud (Intersection) ?