KMT2B and RAP1B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KMT2B	RAP1B
Gene Name		lysine (K)-specific methyltransferase 2B	RAP1B, member of RAS oncogene family
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Intracellular Lipid Particle Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific)	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding
	Biological Process	Ovarian Follicle Development Chromatin Organization Transcription, DNA-templated Oocyte Differentiation Gene Silencing Ovulation Chromatin-mediated Maintenance Of Transcription Histone H3-K4 Methylation Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation	Blood Coagulation Cell Proliferation Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Rap1 signalling p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS			White blood cell count ( 20139978)
Protein-Protein Interactions		22 interactors: ANXA1 ANXA7 ATP1B1 ATXN1 CDKN1A GRB7 HIST1H3A HIST2H3C NREP PIN1 PRPF40A RAP1B RCC1 RPP14 SEPT8 SMAD3 SMARCB1 SMN1 TK1 TSC22D1 WDR5 ZNF512B	29 interactors: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		9757	5908
HPRD ID		06017	01546
Ensembl ID		ENSG00000272333	ENSG00000127314
Uniprot IDs		Q9UMN6	B7ZAY2 P61224
PDB IDs		3UVM 4ERZ	3BRW 3CF6 4DXA 4HDO 4HDQ
Enriched GO Terms of Interacting Partners?		Hemostasis Response To Wounding Regulation Of Body Fluid Levels Response To Stress Wound Healing Regulation Of Mitotic Cell Cycle Blood Coagulation Nucleobase-containing Compound Metabolic Process DNA Methylation On Cytosine Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Regulation Of Metabolic Process Chromatin Silencing At RDNA Cellular Nitrogen Compound Metabolic Process Epithelial Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Cyclic Compound Gene Silencing Negative Regulation Of Gene Expression Cell Cycle Regulation Of Cell Cycle Regulation Of Cellular Component Organization Digestive Tract Development Nitrogen Compound Metabolic Process Digestive System Development Response To Abiotic Stimulus Liver Development Response To X-ray Response To Glucocorticoid Positive Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Phosphorylation Gene Expression Response To Corticosteroid Chromatin Silencing Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression, Epigenetic Neutrophil Clearance Positive Regulation Of Transforming Growth Factor Beta3 Production Fetal Process Involved In Parturition Regulation Of Cell Junction Assembly RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokinesis DNA Methylation Cellular Process Regulation Of Cell Division RNA Processing Mitotic Cell Cycle Phase Transition	Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorylation Response To Radiation Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cell Communication Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Negative Regulation Of Hydrolase Activity Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Neurotrophin Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Component Organization
Tagcloud ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2a landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Difference) ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2a landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Intersection) ?