KMT2B and TK1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KMT2B	TK1
Gene Name		lysine (K)-specific methyltransferase 2B	thymidine kinase 1, soluble
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific)	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding
	Biological Process	Ovarian Follicle Development Chromatin Organization Transcription, DNA-templated Oocyte Differentiation Gene Silencing Ovulation Chromatin-mediated Maintenance Of Transcription Histone H3-K4 Methylation Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides
Drugs			Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS
Protein-Protein Interactions		22 interactors: ANXA1 ANXA7 ATP1B1 ATXN1 CDKN1A GRB7 HIST1H3A HIST2H3C NREP PIN1 PRPF40A RAP1B RCC1 RPP14 SEPT8 SMAD3 SMARCB1 SMN1 TK1 TSC22D1 WDR5 ZNF512B	159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC
Entrez ID		9757	7083
HPRD ID		06017	01771
Ensembl ID		ENSG00000272333	ENSG00000167900
Uniprot IDs		Q9UMN6	P04183
PDB IDs		3UVM 4ERZ	1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Hemostasis Response To Wounding Regulation Of Body Fluid Levels Response To Stress Wound Healing Regulation Of Mitotic Cell Cycle Blood Coagulation Nucleobase-containing Compound Metabolic Process DNA Methylation On Cytosine Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Regulation Of Metabolic Process Chromatin Silencing At RDNA Cellular Nitrogen Compound Metabolic Process Epithelial Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Cyclic Compound Gene Silencing Negative Regulation Of Gene Expression Cell Cycle Regulation Of Cell Cycle Regulation Of Cellular Component Organization Digestive Tract Development Nitrogen Compound Metabolic Process Digestive System Development Response To Abiotic Stimulus Liver Development Response To X-ray Response To Glucocorticoid Positive Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Phosphorylation Gene Expression Response To Corticosteroid Chromatin Silencing Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression, Epigenetic Neutrophil Clearance Positive Regulation Of Transforming Growth Factor Beta3 Production Fetal Process Involved In Parturition Regulation Of Cell Junction Assembly RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokinesis DNA Methylation Cellular Process Regulation Of Cell Division RNA Processing Mitotic Cell Cycle Phase Transition	Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus
Tagcloud ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2a landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Difference) ?		alters associates demethylase h3k4 h3k4me3 hmt hyperplastic igf2bp2 integrative interactive islet islets jarid1 jumonji kdm5a kmt2a landscape men1 menin methyltransferases mll1 mll4 neuroendocrine pancreatic pannets rbp2 seq trimethylation unbiased	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Intersection) ?