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TRAF4 and TRIM37
Number of citations of the paper that reports this interaction (PMID
11279055
)
30
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
TRAF4
TRIM37
Gene Name
TNF receptor-associated factor 4
tripartite motif containing 37
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytoskeleton
Plasma Membrane
Tight Junction
Perinuclear Region Of Cytoplasm
Cytoplasm
Peroxisome
Cytosol
Aggresome
ESC/E(Z) Complex
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
WW Domain Binding
Chromatin Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Biological Process
Apoptotic Process
Signal Transduction
Activation Of NF-kappaB-inducing Kinase Activity
Respiratory Gaseous Exchange
Protein Ubiquitination
Respiratory Tube Development
Regulation Of Apoptotic Process
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Positive Regulation Of Protein Homodimerization Activity
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of NF-kappaB Transcription Factor Activity
Histone H2A Monoubiquitination
Histone H2A-K119 Monoubiquitination
Negative Regulation Of Centriole Replication
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Aggresome Assembly
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Testicular germ cell tumor (
23666239
)
Protein-Protein Interactions
69 interactors:
ALKBH4
ARNT2
BAHD1
BANP
BCKDK
BCL6B
BYSL
CALCOCO2
CBL
CBLC
CCHCR1
CENPE
CHUK
DTX3
EXOC7
FBXL18
FTH1
GORASP2
GPRASP1
HOMEZ
IRAK1
ISYNA1
KANSL1
KDM1A
KRT31
KRT40
LTBR
MAGED1
MAP3K4
MRPL28
NCF1
NGFR
NGFRAP1
NOS1AP
NPAS2
PDE4DIP
PKD1P1
PLSCR1
PSMC3
QARS
REXO1L6P
RNF114
RPS6KB1
SIGLEC7
SMURF1
SMURF2
SORBS2
SPDL1
SUMO1
TARBP2
TBC1D7
TBC1D8
TGFB1I1
TICAM1
TNFRSF4
TP53BP2
TRAF6
TRIM37
TYK2
UBE2I
UBL4A
UBL4B
USP7
WBP11
WWP1
WWP2
ZNF3
ZNF512B
ZNF581
59 interactors:
ANKRD11
APEX2
APTX
ARNT2
BYSL
CCDC33
CDC20B
CDK5RAP2
COPB1
CWF19L2
DDX6
DLGAP5
EWSR1
FAM107A
FAM124B
FAM161A
FAM50B
FXR2
KAT5
KIAA0408
KIF9
LTBR
MAGEB18
MCM10
MCRS1
NGFR
NUDT18
PBK
PNKP
PRC1
RASD1
RHPN1
RIBC2
RPL9
SCNM1
SSX2IP
TANK
TCEB3B
TNFRSF1B
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
UBASH3A
UBB
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2U
ZMAT2
ZNF329
ZNF417
ZNF655
Entrez ID
9618
4591
HPRD ID
03915
05463
Ensembl ID
ENSG00000076604
ENSG00000108395
Uniprot IDs
Q9BUZ4
A8K0V9
A8K8U4
F8WEE6
O94972
PDB IDs
2EOD
2YUC
4M4E
3LRQ
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein Ubiquitination
Regulation Of Gene Expression
Regulation Of Signal Transduction
Regulation Of Metabolic Process
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Signaling
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Response To Growth Factor
Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Cellular Protein Modification Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Response To Organic Substance
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Programmed Cell Death
Proteolysis Involved In Cellular Protein Catabolic Process
Response To Cytokine
Cellular Protein Catabolic Process
Cell Death
Death
Protein Metabolic Process
Cellular Response To Organic Substance
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Protein Catabolic Process
Protein Polyubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein K48-linked Ubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Cellular Macromolecule Catabolic Process
Regulation Of Innate Immune Response
Protein K11-linked Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein K63-linked Ubiquitination
Cellular Response To Stress
Catabolic Process
Polynucleotide 3' Dephosphorylation
Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Protein Catabolic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of DNA-templated Transcription In Response To Stress
Programmed Cell Death
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To DNA Damage Stimulus
Regulation Of Cell Cycle Phase Transition
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteolysis
Cell Death
Death
Activation Of NF-kappaB-inducing Kinase Activity
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of NIK/NF-kappaB Signaling
Cellular Protein Catabolic Process
DNA Repair
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Proteolysis
Regulation Of Stress-activated MAPK Cascade
NIK/NF-kappaB Signaling
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Metabolic Process
Tagcloud
?
bcr
cart
cd40
cd54
cd95
ciap2
define
dr3
driven
effector
engagement
fas
icam
linking
mapk
mapkapk
minimal
p38
permeable
perturbed
potentiating
requirement
responsive
sb203580
selectively
stimulates
tonsillar
traf1
unaffected
Tagcloud (Difference)
?
bcr
cart
cd40
cd54
cd95
ciap2
define
dr3
driven
effector
engagement
fas
icam
linking
mapk
mapkapk
minimal
p38
permeable
perturbed
potentiating
requirement
responsive
sb203580
selectively
stimulates
tonsillar
traf1
unaffected
Tagcloud (Intersection)
?