TRIM37 and NUDT18

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM37	NUDT18
Gene Name		tripartite motif containing 37	nudix (nucleoside diphosphate linked moiety X)-type motif 18
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Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Magnesium Ion Binding Protein Binding 8-oxo-dGDP Phosphatase Activity 8-oxo-GDP Phosphatase Activity 8-hydroxy-dADP Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly	Nucleobase-containing Small Molecule Catabolic Process Small Molecule Metabolic Process DADP Catabolic Process DGDP Catabolic Process GDP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655	34 interactors: APIP COIL CUTC DCTD DHPS DUT EVI5L GLUL GNMT GSE1 HSD17B14 KCTD13 KCTD17 KHDRBS3 KRT15 KRTAP4-12 KXD1 NADK NAT9 NT5C2 PAICS PCBD1 PSME3 RAB3IL1 RABAC1 RAD54B RWDD1 SDPR TARBP2 TERF2IP TIFA TRAF2 TRIM37 ZBED1
Entrez ID		4591	79873
HPRD ID		05463	07992
Ensembl ID		ENSG00000108395
Uniprot IDs		A8K0V9 A8K8U4 F8WEE6 O94972	Q6ZVK8
PDB IDs		3LRQ	3GG6
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process	Protein Homooligomerization Protein Oligomerization Nucleoside Metabolic Process Protein Tetramerization Nucleobase-containing Small Molecule Metabolic Process Protein Complex Assembly Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Protein Homotetramerization Nitrogen Compound Metabolic Process Catabolic Process Small Molecule Metabolic Process S-adenosylmethionine Metabolic Process Purine Nucleoside Metabolic Process Methionine Metabolic Process Regulation Of Protein Homodimerization Activity IMP Metabolic Process Alpha-amino Acid Metabolic Process Nucleotide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide Metabolic Process Polyamine Metabolic Process Cofactor Metabolic Process Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Protein Autoubiquitination Purine Nucleobase Metabolic Process Sulfur Amino Acid Metabolic Process DUMP Biosynthetic Process Deoxyhypusine Biosynthetic Process From Spermidine DUTP Catabolic Process Negative Regulation Of DNA Recombination At Telomere Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Pyrimidine Nucleoside Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Amino Acid Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Glutamine Biosynthetic Process MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Spermidine Catabolic Process L-methionine Biosynthetic Process From S-adenosylmethionine Cellular Modified Amino Acid Metabolic Process Pyrimidine Nucleotide Metabolic Process Pyrimidine Nucleoside Metabolic Process Targeting Of MRNA For Destruction Involved In RNA Interference DUMP Metabolic Process NADP Biosynthetic Process DUTP Metabolic Process Negative Regulation Of Cilium Assembly
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