PRPF3 and DPY30

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRPF3	DPY30
Gene Name		pre-mRNA processing factor 3	dpy-30 homolog (C. elegans)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Protein Binding Identical Protein Binding Poly(A) RNA Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endosomal Transport Histone H3-K4 Methylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: BRCA1 CCDC85B CDC5L CTNNBL1 DPY30 DVL2 DVL3 FAM9B FRA10AC1 GTPBP3 NHP2L1 NKAP PCBP1 PPIH PRPF31 PRPF4 RBM39 SART3 SNIP1 TRIM39 U2AF2 USP4 WBP4 ZCCHC10	10 interactors: ARFGEF1 ASH2L CHMP2B DYDC1 GTF2I HIST3H3 PRPF3 PSMD14 SETD1A TMCC2
Entrez ID		9129	84661
HPRD ID		07389	17434
Ensembl ID		ENSG00000117360
Uniprot IDs		E7EVD1 O43395	B4DIS3 Q9C005
PDB IDs		1X4Q	3G36
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Spliceosomal Tri-snRNP Complex Assembly Cellular Metabolic Process Spliceosomal SnRNP Assembly Hematopoietic Stem Cell Proliferation Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Wnt Signaling Pathway, Planar Cell Polarity Pathway Ribonucleoprotein Complex Biogenesis Metabolic Process Cochlea Morphogenesis Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Ribonucleoprotein Complex Assembly Regulation Of Protein Ubiquitination Cochlea Development Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone Deubiquitination Positive Regulation Of Histone H4-K16 Acetylation Outflow Tract Morphogenesis Positive Regulation Of Histone Modification Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of JUN Kinase Activity Cellular Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of JUN Kinase Activity Stem Cell Proliferation Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Signal Transduction In Response To DNA Damage RNA Biosynthetic Process Canonical Wnt Signaling Pathway Regulation Of Metabolic Process Inner Ear Morphogenesis Negative Regulation Of Protein Ubiquitination Non-canonical Wnt Signaling Pathway Via JNK Cascade	Histone H3-K4 Methylation Chromosome Organization Positive Regulation Of Protein Glycosylation In Golgi Histone Lysine Methylation Peptidyl-lysine Methylation Transition Between Slow And Fast Fiber Histone Methylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Protein Glycosylation Cellular Aromatic Compound Metabolic Process Protein Methylation Organelle Organization Cellular Nitrogen Compound Metabolic Process Viral Budding Via Host ESCRT Complex Gene Expression Nitrogen Compound Metabolic Process Regulation Of Skeletal Muscle Adaptation Regulation Of Mitotic Spindle Assembly Negative Regulation Of Cytosolic Calcium Ion Concentration Viral Budding Peptidyl-lysine Modification Regulation Of Spindle Assembly Regulation Of Protein Glycosylation Regulation Of Mitotic Spindle Organization Negative Regulation Of Rho GTPase Activity Spliceosomal Tri-snRNP Complex Assembly Positive Regulation Of Glycoprotein Biosynthetic Process Regulation Of Protein Complex Assembly Positive Regulation Of Glycoprotein Metabolic Process Protein K63-linked Deubiquitination Cell Separation After Cytokinesis
Tagcloud ?		accumulative assumes debilitating decades degeneration developmentally example focused hypotheses hypothesis implying interacting interrupt intriguing metabolically methodology mildly phenomenon photoreceptors principal prp31 prpc8 retina retinal rp18 snrnas splicing suboptimal ubiquitously	acidic allosterically ash2l box compass composed concave erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Difference) ?		accumulative assumes debilitating decades degeneration developmentally example focused hypotheses hypothesis implying interacting interrupt intriguing metabolically methodology mildly phenomenon photoreceptors principal prp31 prpc8 retina retinal rp18 snrnas splicing suboptimal ubiquitously	acidic allosterically ash2l box compass composed concave erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Intersection) ?