KAT2B and HTT

Number of citations of the paper that reports this interaction (PMID 11607033)
235

Data Source:
BioGRID (pull down)

		KAT2B	HTT
Gene Name		K(lysine) acetyltransferase 2B	huntingtin
Image
Gene Ontology Annotations	Cellular Component	PCAF Complex Kinetochore Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex A Band I Band Actomyosin	Nucleus Nucleoplasm Cytoplasm Mitochondrion Late Endosome Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Protein Complex
	Molecular Function	Transcription Cofactor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Protein Kinase Binding Protein Complex Binding Histone Deacetylase Binding	P53 Binding Protein Binding Transcription Factor Binding Dynactin Binding Identical Protein Binding Ion Channel Binding Dynein Intermediate Chain Binding Beta-tubulin Binding Diazepam Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase II Promoter Protein Acetylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Gene Expression Regulation Of Protein ADP-ribosylation Viral Process N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Cellular Response To Insulin Stimulus Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H3-K9 Acetylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process	Urea Cycle Citrulline Metabolic Process Establishment Of Mitotic Spindle Orientation Protein Import Into Nucleus ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Endoplasmic Reticulum Organization Golgi Organization Dopamine Receptor Signaling Pathway Spermatogenesis Cell Aging Grooming Behavior Locomotory Behavior Axon Cargo Transport Determination Of Adult Lifespan Visual Learning Anterior/posterior Pattern Specification Endosomal Transport Lactate Biosynthetic Process From Pyruvate Quinolinate Biosynthetic Process Striatum Development Olfactory Lobe Development Neural Plate Formation Insulin Secretion Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Social Behavior Hormone Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Vesicle Transport Along Microtubule Regulation Of Synaptic Plasticity Paraxial Mesoderm Formation Organ Development Neuron Development Neuron Apoptotic Process Response To Calcium Ion Regulation Of Mitochondrial Membrane Potential L-glutamate Import Iron Ion Homeostasis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		116 interactors: ACTN1 ACTN2 AKT1 AR ARNTL ATF4 ATXN3 BRCA2 CCNA2 CCND1 CCNT1 CDC25B CDCA4 CDK2 CDKN1B CDT1 CEBPB CEP250 CIITA CLOCK CNTN2 CREBBP CTBP1 CTNNB1 CUX1 DACH2 DEK EP300 ESRRA ETV1 GATAD2A GATAD2B H3F3A HIPK2 HIST1H1A HIST1H1B HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST3H3 HIST4H4 HMGA1 HMGN2 HNF1A HNRNPU HSD11B2 HTT ING1 IRF1 IRF2 IRF7 JDP2 KLF10 KLF13 KLF2 MAPK14 MAPRE1 MDM2 MECOM MYC MYOD1 NCOA1 NCOA3 NCOA4 NFATC1 NFE2 NFE4 NOTCH1 NOTCH3 NPAS2 NR1H3 NR4A1 NRIP1 ONECUT1 PARP1 PDK1 PGR PLAGL1 PNMA1 POLR2A PTF1A RAB11A RARA RB1 RBPJ RELA RPS6KB1 RPS6KB2 SAT2 SATB1 SERBP1 SERTAD1 SERTAD2 SIRT2 SMAD1 SMAD2 SMAD3 SRC SRCAP TACC2 TAL1 TCF3 TMF1 TP53 TP63 TP73 TTF1 TWIST1 UBE2D1 UBE2D3 XRCC6 YY1	108 interactors: AKT1 AMFR AP2A2 CASP1 CASP3 CASP6 CBS CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 HAP1 HEYL HIP1 HIP1R HIST1H3H HOXC11 HOXC4 HSPA8 HYPK HYPM IFT20 IKBKAP IKBKB IKBKG ING5 KAT2B KIAA1377 MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUPL1 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 RASA1 REST RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655
Entrez ID		8850	3064
HPRD ID		06780	00883
Ensembl ID		ENSG00000114166	ENSG00000197386
Uniprot IDs		Q92831	P42858
PDB IDs		1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3	2D3X 2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Chromosome Organization Chromatin Organization Response To Stress Regulation Of Cell Differentiation Response To Organic Substance Regulation Of Cell Proliferation Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Response To Organic Substance Organelle Organization System Development Developmental Process Cellular Metabolic Process Anatomical Structure Development	Positive Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Response To Growth Factor Cellular Response To Organic Substance Macromolecule Biosynthetic Process Viral Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Response To Organic Substance Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Signaling Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Developmental Process Transcription From RNA Polymerase II Promoter Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Communication Regulation Of Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process
Tagcloud ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	1s 2a 3s 4c 4r 9r aryl carbomethoxy carboxylic dat esters ethylene flattened fluorophenyl isomers methylenedioxy nortropane paroxetine phenoxy piperidine possesses pseudoequatorial reuptake serotonin ssri stereochemistry substituent substituents win
Tagcloud (Difference) ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	1s 2a 3s 4c 4r 9r aryl carbomethoxy carboxylic dat esters ethylene flattened fluorophenyl isomers methylenedioxy nortropane paroxetine phenoxy piperidine possesses pseudoequatorial reuptake serotonin ssri stereochemistry substituent substituents win
Tagcloud (Intersection) ?