KAT2B and NPAS2

Number of citations of the paper that reports this interaction (PMID 14645221)
43

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KAT2B	NPAS2
Gene Name		K(lysine) acetyltransferase 2B	neuronal PAS domain protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	PCAF Complex Kinetochore Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex A Band I Band Actomyosin	Nucleus Transcription Factor Complex Cytosol
	Molecular Function	Transcription Cofactor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Protein Kinase Binding Protein Complex Binding Histone Deacetylase Binding	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase II Promoter Protein Acetylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Gene Expression Regulation Of Protein ADP-ribosylation Viral Process N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Cellular Response To Insulin Stimulus Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H3-K9 Acetylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process	Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Signal Transduction Central Nervous System Development Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Sleep/wake Cycle Cellular Lipid Metabolic Process Small Molecule Metabolic Process Locomotor Rhythm Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Redox State Negative Regulation Of Cell Death Regulation Of Response To DNA Damage Stimulus
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Constitutive Signaling by NOTCH1 PEST Domain Mutants	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS			Creutzfeldt-Jakob disease (variant) ( 22137330)
Protein-Protein Interactions		116 interactors: ACTN1 ACTN2 AKT1 AR ARNTL ATF4 ATXN3 BRCA2 CCNA2 CCND1 CCNT1 CDC25B CDCA4 CDK2 CDKN1B CDT1 CEBPB CEP250 CIITA CLOCK CNTN2 CREBBP CTBP1 CTNNB1 CUX1 DACH2 DEK EP300 ESRRA ETV1 GATAD2A GATAD2B H3F3A HIPK2 HIST1H1A HIST1H1B HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST3H3 HIST4H4 HMGA1 HMGN2 HNF1A HNRNPU HSD11B2 HTT ING1 IRF1 IRF2 IRF7 JDP2 KLF10 KLF13 KLF2 MAPK14 MAPRE1 MDM2 MECOM MYC MYOD1 NCOA1 NCOA3 NCOA4 NFATC1 NFE2 NFE4 NOTCH1 NOTCH3 NPAS2 NR1H3 NR4A1 NRIP1 ONECUT1 PARP1 PDK1 PGR PLAGL1 PNMA1 POLR2A PTF1A RAB11A RARA RB1 RBPJ RELA RPS6KB1 RPS6KB2 SAT2 SATB1 SERBP1 SERTAD1 SERTAD2 SIRT2 SMAD1 SMAD2 SMAD3 SRC SRCAP TACC2 TAL1 TCF3 TMF1 TP53 TP63 TP73 TTF1 TWIST1 UBE2D1 UBE2D3 XRCC6 YY1	19 interactors: ARNT2 ARNTL ARNTL2 CREBBP CRX EFS EP300 HESX1 HGS HSP90AA1 KAT2B NCOA3 RARA RASSF7 RHOXF1 RPL6 RXRA TRAF4 ZSCAN1
Entrez ID		8850	4862
HPRD ID		06780	09137
Ensembl ID		ENSG00000114166	ENSG00000170485
Uniprot IDs		Q92831	A2I2P5 F5H027 Q99743
PDB IDs		1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Chromosome Organization Chromatin Organization Response To Stress Regulation Of Cell Differentiation Response To Organic Substance Regulation Of Cell Proliferation Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Response To Organic Substance Organelle Organization System Development Developmental Process Cellular Metabolic Process Anatomical Structure Development	RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression N-terminal Protein Amino Acid Acetylation Rhythmic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signal Transduction Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Communication Biosynthetic Process Cellular Nitrogen Compound Metabolic Process N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Histone Acetylation Regulation Of Cellular Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Circadian Rhythm Response To Stimulus Intracellular Receptor Signaling Pathway Embryo Development Cellular Response To Heat Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	additively bmal1 box circadian clock electrophoretic ems fold heme heterodimer homodimer kd kinetics luciferase maximal metabolite mixture mobility monoxide nad nadph nih3t3 ph rhythms sense sensor shift truncated
Tagcloud (Difference) ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	additively bmal1 box circadian clock electrophoretic ems fold heme heterodimer homodimer kd kinetics luciferase maximal metabolite mixture mobility monoxide nad nadph nih3t3 ph rhythms sense sensor shift truncated
Tagcloud (Intersection) ?