HTT and REST

Number of citations of the paper that reports this interaction (PMID 12881722)
155

Data Source:
HPRD (in vivo)

		HTT	REST
Gene Name		huntingtin	RE1-silencing transcription factor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Late Endosome Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Protein Complex	Nucleus Nucleoplasm Cytosol Transcriptional Repressor Complex
	Molecular Function	P53 Binding Protein Binding Transcription Factor Binding Dynactin Binding Identical Protein Binding Ion Channel Binding Dynein Intermediate Chain Binding Beta-tubulin Binding Diazepam Binding	Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Outward Rectifier Potassium Channel Activity Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Urea Cycle Citrulline Metabolic Process Establishment Of Mitotic Spindle Orientation Protein Import Into Nucleus ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Endoplasmic Reticulum Organization Golgi Organization Dopamine Receptor Signaling Pathway Spermatogenesis Cell Aging Grooming Behavior Locomotory Behavior Axon Cargo Transport Determination Of Adult Lifespan Visual Learning Anterior/posterior Pattern Specification Endosomal Transport Lactate Biosynthetic Process From Pyruvate Quinolinate Biosynthetic Process Striatum Development Olfactory Lobe Development Neural Plate Formation Insulin Secretion Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Social Behavior Hormone Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Vesicle Transport Along Microtubule Regulation Of Synaptic Plasticity Paraxial Mesoderm Formation Organ Development Neuron Development Neuron Apoptotic Process Response To Calcium Ion Regulation Of Mitochondrial Membrane Potential L-glutamate Import Iron Ion Homeostasis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Hematopoietic Progenitor Cell Differentiation Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Aldosterone Biosynthetic Process Cellular Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Cardiac Muscle Cell Myoblast Differentiation Histone H4 Deacetylation Cellular Response To Electrical Stimulus Cellular Response To Glucocorticoid Stimulus Potassium Ion Transmembrane Transport Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Amniotic Stem Cell Differentiation
Pathways			Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones
Drugs
Diseases
GWAS			Age-related macular degeneration ( 21909106) Bleomycin sensitivity ( 21106707)
Protein-Protein Interactions		108 interactors: AKT1 AMFR AP2A2 CASP1 CASP3 CASP6 CBS CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 HAP1 HEYL HIP1 HIP1R HIST1H3H HOXC11 HOXC4 HSPA8 HYPK HYPM IFT20 IKBKAP IKBKB IKBKG ING5 KAT2B KIAA1377 MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUPL1 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 RASA1 REST RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655	7 interactors: CDYL GTF2B HTT RCOR1 SIN3B SUB1 TBP
Entrez ID		3064	5978
HPRD ID		00883	08990
Ensembl ID		ENSG00000197386	ENSG00000084093
Uniprot IDs		P42858	Q13127
PDB IDs		2D3X 2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED	2CZY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Response To Growth Factor Cellular Response To Organic Substance Macromolecule Biosynthetic Process Viral Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Response To Organic Substance Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Signaling Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Developmental Process Transcription From RNA Polymerase II Promoter Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Communication Regulation Of Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter Histone Modification Histone Deacetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Deacetylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Elongation Regulation Of RNA Metabolic Process Neural Plate Formation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Spermatogenesis Male Gamete Generation Regulation Of Metabolic Process Viral Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Gamete Generation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Phosphatase Type 2A Activity Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Lactate Biosynthetic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Paraxial Mesoderm Formation Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		1s 2a 3s 4c 4r 9r aryl carbomethoxy carboxylic dat esters ethylene flattened fluorophenyl isomers methylenedioxy nortropane paroxetine phenoxy piperidine possesses pseudoequatorial reuptake serotonin ssri stereochemistry substituent substituents win	areas bph cellular coefficient composition depends dpv equation glands granular histological mathematical mm2 morphometric mu2 ncr pearson prostate prostatic random secreto ser stroma sum transurethral us vascularization vessels volume
Tagcloud (Difference) ?		1s 2a 3s 4c 4r 9r aryl carbomethoxy carboxylic dat esters ethylene flattened fluorophenyl isomers methylenedioxy nortropane paroxetine phenoxy piperidine possesses pseudoequatorial reuptake serotonin ssri stereochemistry substituent substituents win	areas bph cellular coefficient composition depends dpv equation glands granular histological mathematical mm2 morphometric mu2 ncr pearson prostate prostatic random secreto ser stroma sum transurethral us vascularization vessels volume
Tagcloud (Intersection) ?